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    LOC126861876 P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:114852049-114853248 [ Homo sapiens (human) ]

    Gene ID: 126861876, updated on 10-Oct-2023

    Summary

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    Gene symbol
    LOC126861876
    Gene description
    P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:114852049-114853248
    Gene type
    biological region
    Feature type(s)
    regulatory: enhancer
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This genomic region was validated as an active enhancer by the STARR-seq (self-transcribing active regulatory region sequencing) massively parallel reporter assay in HCT116 colorectal carcinoma cells. This sequence was defined as a group 1 enhancer that depends on the BRD2, BRD4, P300/CBP, MED14 and CDK7 cofactors, with strong dependence on P300/CBP. [provided by RefSeq, Sep 2022]
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    Genomic context

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    Location:
    chromosome: 13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (114086574..114087773)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (113293055..113294254)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 452 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:114616152-114617351 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114622697-114623581 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8045 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114638965-114639466 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114639467-114639966 Neighboring gene chromosome 13 open reading frame 46 Neighboring gene SWI/SNF complex interacting GAS6 enhancer non-coding RNA Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114748299-114748799 Neighboring gene RAS p21 protein activator 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114789740-114790579 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114796667-114797608 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:114801666-114802865 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114804717-114805611 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8047 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114812769-114813560 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114813561-114814350 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114829337-114829856 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8048 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8049 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8050 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5555 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8052 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8053 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8054 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:114838566-114839765 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr13:114848666-114849865 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:114875547-114876182 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:114876854-114877008 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr13:114878083-114878678 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:114878884-114880083 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:114880307-114881171 Neighboring gene uncharacterized LOC124903221 Neighboring gene RASA3 intronic transcript 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential cofactor dependencies define distinct types of human enhancers. Neumayr C, et al. Nature, 2022 Jun. PMID 35650434, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_086374.1 

      Range
      101..1300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      114086574..114087773
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_011332698.1 Reference GRCh38.p14 PATCHES

      Range
      145665..146864
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      113293055..113294254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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