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| Status |
Public on Mar 12, 2018 |
| Title |
Development, phenotype and function of a distinct macrophage subpopulation induced by IL-23 |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Macrophages acquire distinct phenotypes during tissue stress and inflammatory responses. Classically, macrophages are categorized into two different subsets named inflammatory M1 and anti-inflammatory M2 macrophages. We herein identified a unique pathogenic macrophage subpopulation, named M17, driven by IL-23 with a distinct gene expression profile including cytokines and membrane molecules. In contrast to M1 and M2-polarized macrophages, M17 macrophages express high levels of CXCR5 on the cell surface and produce large amounts of IL-17A, IL-22 and IFN-γ. IL-23 induces IL-17A expression in macrophages through the signal transducer and activator of transcription 3 (STAT3)-retinoid related orphan receptor-γ T (RORγT) pathway, while induces IFN-γ through T-bet. Importantly, IL-23-induced M17 macrophage polarization promotes the pathogenesis of psoriasis in vivo. The characteristics and significances of M17 macrophage subpopulation in the physiological status and pathogenesis caused by infections, tumors and graft rejection needs to be explored.
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| Overall design |
To further demonstrate whether M17 macrophage polarization represents a distinct polarization of macrophages, we detected gene expression profiles of M1, M2 and M17 polarized macrophages by microarray methods.
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| Contributor(s) |
Hou Y, Zhu L, Tian H, Sun H, Sun C, Chen H, Wu T, Hu X, Li B, Lu J, Zhang L, Wang R, Zhao Y |
| Citation(s) |
29508278 |
| Submission date |
Aug 04, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Yong Zhao |
| E-mail(s) |
zhaoy@ioz.ac.cn
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| Phone |
+86-10-64807302
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| Organization name |
Institute of Zoology, Chinese Academy of Sciences
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| Department |
State Key Laboratory of Biomembrane and Membrane Biotechnology
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| Lab |
TBRD
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| Street address |
1 Beichen West Road, Chaoyang District
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| City |
Beijing |
| ZIP/Postal code |
100101 |
| Country |
China |
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| Platforms (1) |
| GPL7202 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA397193 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE102274_Processed_data.xlsx |
10.5 Mb |
(ftp)(http) |
XLSX |
| GSE102274_RAW.tar |
37.3 Mb |
(http)(custom) |
TAR (of TXT) |
| Processed data included within Sample table |
| Processed data are available on Series record |
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