|
| Status |
Public on Dec 01, 2018 |
| Title |
Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator [ChIP-seq] |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
EZH2 induces active transcription of the AR gene, thereby increasing AR level and promoting AR signaling. Importantly, EZH2-mediated activation of AR requires EZH2 protein occupancy at the AR gene promoter, but is independent of PRC2 as well as its histone methyltransferase activity
|
| |
|
| Overall design |
ChIP-seq examination of EZH2 binding sites in LNCaP cells
|
| |
|
| Contributor(s) |
Yu J, Kim J |
| Citation(s) |
30517868 |
| Submission date |
Dec 06, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Jindan Yu |
| E-mail(s) |
jindan.yu@emory.edu
|
| Organization name |
Emory University
|
| Department |
Urology
|
| Lab |
Jindan Yu's lab
|
| Street address |
E330, 1760 Haygood Dr NE
|
| City |
Atlanta |
| State/province |
GA |
| ZIP/Postal code |
30322 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL15456 |
Illumina HiScanSQ (Homo sapiens) |
|
| Samples (9)
|
|
| This SubSeries is part of SuperSeries: |
| GSE107782 |
Polycomb- and Methylation-Independent Roles of EZH2 as a Transcription Activator |
|
| Relations |
| BioProject |
PRJNA421359 |
| SRA |
SRP126287 |
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