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Status |
Public on Dec 21, 2018 |
Title |
In vitro transcription studies used in a proof of concept whole transcriptome model predition study - HepaRG cells (3 of 4) |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
HepaRG cells were exposed in triplicate to three agrichemicals for 24hrs at 8 concentrations and a DMSO vehicle control (0.001, 0.003, 0.01, 0.03, 0.1, 0.3, 1, 3, and 10 μM plus DMSO vehicle controls). While a common set of DMSO controls was used, these CEL files were RMA normalized independently with each of the chemical treated groups. Gene expression was measured on an Affymetrix GeneTitan system. The compounds used were fenbuconazole (a.k.a FENB, CAS # 114369-43-6) a triazole fungicide, imazalil (a.k.a. IMAZ, CAS # 35554-44-0), an azole pesticide, and 2,4-dichlorophenoxyacetic acid (a.k.a. 2,4-D or 2-4-D in file names, CAS # 94-75-7), a chlorophenoxy herbicide.
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Overall design |
24hr in vitro exposures in triplicate at 9 concentrations - 0.001, 0.003, 0.01, 0.03, 0.1, 0.3, 1, 3, and 10 μM plus DMSO vehicle controls
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Contributor(s) |
Black MB, Haider S |
Citation(s) |
30333746 |
Submission date |
Jan 23, 2018 |
Last update date |
Dec 23, 2018 |
Contact name |
Michael B. Black |
E-mail(s) |
mblack@scitovation.com
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Phone |
919-354-5223
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Organization name |
Scitovation, LLC.
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Street address |
100 Capitola Dr., Suite 106
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City |
Research Triangle Park |
State/province |
North Carolina |
ZIP/Postal code |
27713 |
Country |
USA |
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Platforms (1) |
GPL13158 |
[HT_HG-U133_Plus_PM] Affymetrix HT HG-U133+ PM Array Plate |
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Samples (90)
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GSM2944963 |
HepaRG common DMSO control 1, RMA normalized with FENB samples |
GSM2944964 |
HepaRG common DMSO control 2, RMA normalized with FENB samples |
GSM2944965 |
HepaRG common DMSO control 3, RMA normalized with FENB samples |
GSM2944966 |
HepaRG cells, Fenbuconazole treated at 0.001uM, rep.1 |
GSM2944967 |
HepaRG cells, Fenbuconazole treated at 0.001uM, rep.2 |
GSM2944968 |
HepaRG cells, Fenbuconazole treated at 0.001uM, rep.3 |
GSM2944969 |
HepaRG cells, Fenbuconazole treated at 0.003uM, rep.1 |
GSM2944970 |
HepaRG cells, Fenbuconazole treated at 0.003uM, rep.2 |
GSM2944971 |
HepaRG cells, Fenbuconazole treated at 0.003uM, rep.3 |
GSM2944972 |
HepaRG cells, Fenbuconazole treated at 0.01uM, rep.1 |
GSM2944973 |
HepaRG cells, Fenbuconazole treated at 0.01uM, rep.2 |
GSM2944974 |
HepaRG cells, Fenbuconazole treated at 0.01uM, rep.3 |
GSM2944975 |
HepaRG cells, Fenbuconazole treated at 0.03uM, rep.1 |
GSM2944976 |
HepaRG cells, Fenbuconazole treated at 0.03uM, rep.2 |
GSM2944977 |
HepaRG cells, Fenbuconazole treated at 0.03uM, rep.3 |
GSM2944978 |
HepaRG cells, Fenbuconazole treated at 0.1uM, rep.1 |
GSM2944979 |
HepaRG cells, Fenbuconazole treated at 0.1uM, rep.2 |
GSM2944980 |
HepaRG cells, Fenbuconazole treated at 0.1uM, rep.3 |
GSM2944981 |
HepaRG cells, Fenbuconazole treated at 0.3uM, rep.1 |
GSM2944982 |
HepaRG cells, Fenbuconazole treated at 0.3uM, rep.2 |
GSM2944983 |
HepaRG cells, Fenbuconazole treated at 0.3uM, rep.3 |
GSM2944984 |
HepaRG cells, Fenbuconazole treated at 1uM, rep.1 |
GSM2944985 |
HepaRG cells, Fenbuconazole treated at 1uM, rep.2 |
GSM2944986 |
HepaRG cells, Fenbuconazole treated at 1uM, rep.3 |
GSM2944987 |
HepaRG cells, Fenbuconazole treated at 10uM, rep.1 |
GSM2944988 |
HepaRG cells, Fenbuconazole treated at 10uM, rep.2 |
GSM2944989 |
HepaRG cells, Fenbuconazole treated at 10uM, rep.3 |
GSM2944990 |
HepaRG cells, Fenbuconazole treated at 3uM, rep.1 |
GSM2944991 |
HepaRG cells, Fenbuconazole treated at 3uM, rep.2 |
GSM2944992 |
HepaRG cells, Fenbuconazole treated at 3uM, rep.3 |
GSM2944993 |
HepaRG common DMSO control 1, RMA normalized with IMAZ samples |
GSM2944994 |
HepaRG common DMSO control 2, RMA normalized with IMAZ samples |
GSM2944995 |
HepaRG common DMSO control 3, RMA normalized with IMAZ samples |
GSM2944996 |
HepaRG cells, Imazalil treated at 0.001uM, rep.1 |
GSM2944997 |
HepaRG cells, Imazalil treated at 0.001uM, rep.2 |
GSM2944998 |
HepaRG cells, Imazalil treated at 0.001uM, rep.3 |
GSM2944999 |
HepaRG cells, Imazalil treated at 0.003uM, rep.1 |
GSM2945000 |
HepaRG cells, Imazalil treated at 0.003uM, rep.2 |
GSM2945001 |
HepaRG cells, Imazalil treated at 0.003uM, rep.3 |
GSM2945002 |
HepaRG cells, Imazalil treated at 0.01uM, rep.1 |
GSM2945003 |
HepaRG cells, Imazalil treated at 0.01uM, rep.2 |
GSM2945004 |
HepaRG cells, Imazalil treated at 0.01uM, rep.3 |
GSM2945005 |
HepaRG cells, Imazalil treated at 0.03uM, rep.1 |
GSM2945006 |
HepaRG cells, Imazalil treated at 0.03uM, rep.2 |
GSM2945007 |
HepaRG cells, Imazalil treated at 0.03uM, rep.3 |
GSM2945008 |
HepaRG cells, Imazalil treated at 0.1uM, rep.1 |
GSM2945009 |
HepaRG cells, Imazalil treated at 0.1uM, rep.2 |
GSM2945010 |
HepaRG cells, Imazalil treated at 0.1uM, rep.3 |
GSM2945011 |
HepaRG cells, Imazalil treated at 0.3uM, rep.1 |
GSM2945012 |
HepaRG cells, Imazalil treated at 0.3uM, rep.2 |
GSM2945013 |
HepaRG cells, Imazalil treated at 0.3uM, rep.3 |
GSM2945014 |
HepaRG cells, Imazalil treated at 1uM, rep.1 |
GSM2945015 |
HepaRG cells, Imazalil treated at 1uM, rep.2 |
GSM2945016 |
HepaRG cells, Imazalil treated at 1uM, rep.3 |
GSM2945017 |
HepaRG cells, Imazalil treated at 10uM, rep.1 |
GSM2945018 |
HepaRG cells, Imazalil treated at 10uM, rep.2 |
GSM2945019 |
HepaRG cells, Imazalil treated at 10uM, rep.3 |
GSM2945020 |
HepaRG cells, Imazalil treated at 3uM, rep.1 |
GSM2945021 |
HepaRG cells, Imazalil treated at 3uM, rep.2 |
GSM2945022 |
HepaRG cells, Imazalil treated at 3uM, rep.3 |
GSM2945023 |
HepaRG common DMSO control 1, RMA normalized with 2-4-D samples |
GSM2945024 |
HepaRG common DMSO control 2, RMA normalized with 2-4-D samples |
GSM2945025 |
HepaRG common DMSO control 3, RMA normalized with 2-4-D samples |
GSM2945026 |
HepaRG cells, 2,4-D treated at 0.001uM, rep.1 |
GSM2945027 |
HepaRG cells, 2,4-D treated at 0.001uM, rep.2 |
GSM2945028 |
HepaRG cells, 2,4-D treated at 0.001uM, rep.3 |
GSM2945029 |
HepaRG cells, 2,4-D treated at 0.003uM, rep.1 |
GSM2945030 |
HepaRG cells, 2,4-D treated at 0.003uM, rep.2 |
GSM2945031 |
HepaRG cells, 2,4-D treated at 0.003uM, rep.3 |
GSM2945032 |
HepaRG cells, 2,4-D treated at 0.01uM, rep.1 |
GSM2945033 |
HepaRG cells, 2,4-D treated at 0.01uM, rep.2 |
GSM2945034 |
HepaRG cells, 2,4-D treated at 0.01uM, rep.3 |
GSM2945035 |
HepaRG cells, 2,4-D treated at 0.03uM, rep.1 |
GSM2945036 |
HepaRG cells, 2,4-D treated at 0.03uM, rep.2 |
GSM2945037 |
HepaRG cells, 2,4-D treated at 0.03uM, rep.3 |
GSM2945038 |
HepaRG cells, 2,4-D treated at 0.1uM, rep.1 |
GSM2945039 |
HepaRG cells, 2,4-D treated at 0.1uM, rep.2 |
GSM2945040 |
HepaRG cells, 2,4-D treated at 0.1uM, rep.3 |
GSM2945041 |
HepaRG cells, 2,4-D treated at 0.3uM, rep.1 |
GSM2945042 |
HepaRG cells, 2,4-D treated at 0.3uM, rep.2 |
GSM2945043 |
HepaRG cells, 2,4-D treated at 0.3uM, rep.3 |
GSM2945044 |
HepaRG cells, 2,4-D treated at 1uM, rep.1 |
GSM2945045 |
HepaRG cells, 2,4-D treated at 1uM, rep.2 |
GSM2945046 |
HepaRG cells, 2,4-D treated at 1uM, rep.3 |
GSM2945047 |
HepaRG cells, 2,4-D treated at 10uM, rep.1 |
GSM2945048 |
HepaRG cells, 2,4-D treated at 10uM, rep.2 |
GSM2945049 |
HepaRG cells, 2,4-D treated at 10uM, rep.3 |
GSM2945050 |
HepaRG cells, 2,4-D treated at 3uM, rep.1 |
GSM2945051 |
HepaRG cells, 2,4-D treated at 3uM, rep.2 |
GSM2945052 |
HepaRG cells, 2,4-D treated at 3uM, rep.3 |
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This SubSeries is part of SuperSeries: |
GSE109514 |
In vitro transcription studies used in a proof of concept whole transcriptome model predition study |
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Relations |
BioProject |
PRJNA431292 |
Supplementary file |
Size |
Download |
File type/resource |
GSE109511_RAW.tar |
177.1 Mb |
(http)(custom) |
TAR (of CEL) |
Processed data included within Sample table |
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