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| Status |
Public on Dec 31, 2020 |
| Title |
Genome-wide maps of upregulated or downregulated genes in reconstituted SW48O KOEMT cells without or with a nuclear PTEN (C124S) mutant |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We report that nuclear PTEN negatively regulates DNA-binding activity of SMAD3. We compared upregulated or downregulated genes in colorectal tumor cells without or with a nuclear PTEN (C124S) mutant.
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| Overall design |
RNA-seq analysis of upregulated or downregulated genes in colorectal tumor cells SW480, SW480 with PTEN knockout (SW480 KOEMT), and PTEN-negatvie SW480 reconstituted with a nuclear PTEN (C124S) mutant (SW480 KOEMT + nuclear PTEN [C124S]).
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| Contributor(s) |
Wang Q, Xu W, Guo W |
| Citation missing |
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| Submission date |
Jan 31, 2018 |
| Last update date |
Jan 01, 2021 |
| Contact name |
Wei Guo |
| E-mail(s) |
weiguo@intl.zju.edu.cn
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| Organization name |
Zhejiang University
|
| Department |
ZJU-UoE Institute
|
| Lab |
Wei Guo Laboratory
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| Street address |
718 South Tan Road
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| City |
Haining |
| State/province |
Zhejiang |
| ZIP/Postal code |
314400 |
| Country |
China |
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| Platforms (1) |
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| Samples (3) |
| GSM2974892 |
SW480 RNA-seq |
| GSM2974893 |
SW480_KOEMT cells (PTEN knockout) RNA-seq |
| GSM2974894 |
SW480_KOEMT cells reconstituted with nuclear PTEN (C124S) RNA-seq |
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| Relations |
| BioProject |
PRJNA432438 |
| SRA |
SRP131925 |
