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| Status |
Public on Nov 14, 2019 |
| Title |
Study of sarcopenia in human muscle biopsies of elderly individuals, Hertfordshire Sarcopenia Study |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Purpose: The main goal of this study is to compare skeletal muscle transcriptome profilings derived from sarcopenic versus healthy subjects.
Methods: We use high coverage RNA sequencing of human skeletal muscle biopsies to analyze genome-wide transcriptional changes in human sarcopenia benchmarked to healthy elderly controls.
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| Overall design |
28 muscle biopsies from healthy subjects, 4 muscle biopsies from sarcopenic subjects, 5 muscle biopsies from subjects with only low muscle mass, 3 muscle biopsies from subjects with only low muscle strength or low muscle function.
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| Contributor(s) |
Migliavacca E, Charpagne A, Barton S, Cooper C, Garratt ES, Godfrey KM, Lillycrop KA, Sayer AA, Titcombe P, Westbury L, Patel HP, Syddall HE, Raymond F, Patrick D, Feige JN |
| Citation(s) |
31862890 |
| Submission date |
Feb 22, 2018 |
| Last update date |
Dec 31, 2019 |
| Contact name |
Jerome Feige |
| Organization name |
Nestle Institute Of Health Sciences
|
| Department |
Musculo-Skeletal Health
|
| Street address |
EPFL Innovation Park, Building H
|
| City |
Lausanne |
| ZIP/Postal code |
1015 |
| Country |
Switzerland |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (40)
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| This SubSeries is part of SuperSeries: |
| GSE111017 |
Study of sarcopenia in human muscle biopsies of elderly individuals |
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| Relations |
| BioProject |
PRJNA435580 |
| SRA |
SRP133296 |
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