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Series GSE12102 Query DataSets for GSE12102
Status Public on Jul 15, 2008
Title Overcoming resistance to conventional drugs in Ewing’s sarcoma and identification of molecular predictors of outcome.
Organism Homo sapiens
Experiment type Expression profiling by array
Summary The improvement of Ewing's sarcoma (EWS) therapy is currently linked to find strategies to select patients with poor and good prognosis at diagnosis and to generate modified treatment regimens. In this study, we analyze the molecular factors governing EWS response to chemotherapy in order to identify genetic signatures that may be used for risk-adapted therapy.

Keywords: Gene Expression Analysis.
 
Overall design Affimetrix platform was used for profiling 30 primary tumors of patients that were classified according to event-free survival and 7 metastasis. NED: no evidence of diseaase (event-free); REL: relapse; MET: metastasis. For selected genes, Real-Time PCR was applied in 42 EWS primary tumors as validation assay. MTT test was used to evaluate in vitro drug sensitivity.
 
Contributor(s) Scotlandi K, Remondini D, Castellani G, Manara MC, Nardi F, Cantiani L, Francesconi M, Mercuri M, Caccuri AM, Serra M, Knuutila S, Picci P
Citation(s) 19307502
Submission date Jul 14, 2008
Last update date Mar 25, 2019
Contact name Daniel Remondini
E-mail(s) daniel.remondini@unibo.it
Organization name Bologna University
Department Physics and Astronomy - DIFA
Street address Viale Berti Pichat 6/2
City Bologna
ZIP/Postal code 40127
Country Italy
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (37)
GSM305352 EWS primary tumor relapse (R194)
GSM305353 EWS primary tumor relapse (R29)
GSM305354 EWS primary tumor no evidence of disease (R30)
Relations
BioProject PRJNA113791

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE12102_RAW.tar 162.4 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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