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| Status |
Public on Jun 07, 2019 |
| Title |
Transcriptome analysis of brainstem in gerbils with EV71-infection-induced HFMD |
| Organism |
Meriones unguiculatus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Enterovirus 71 (EV71) is one of the major pathogens associated with human hand, foot, and mouth disease (HFMD) and in some countries this pathogen is the leading cause of this disease. We previously found that CA16 could induce neurological disorders in young gerbils, which could serve as a good animal model for studying the neuropathogenesis of CA16 infection. In this study, we found that 1039 genes were up-regulated and 299 genes were down-regulated in CA16-infected gerbils compared with control. Differentially expressed genes were clustered into functional pathways and the top five pathways according to the enrich factor were viral myocarditis, type 1 diabetes mellitus, toxoplasmosis, toll-like receptor signaling pathway and TNF signaling pathway. Our results provide novel insight into the neuropathogenesis of HFMD induced by CA16 infection.
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| Overall design |
Brainstem mRNA profiles of EV71-infected gerbils were generated by deep sequencing, in triplicate, using Illumina Hiseq.
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| Contributor(s) |
Sun Y, Zhu H |
| Citation(s) |
31906004 |
| Submission date |
Dec 10, 2018 |
| Last update date |
Mar 16, 2020 |
| Contact name |
Yisheng Sun |
| E-mail(s) |
yishengfirst@zju.edu.cn
|
| Phone |
+86-0571-87115316
|
| Organization name |
Zhejiang Provincial Center for Disearse Control and Prevention
|
| Department |
Department of Microbiology
|
| Street address |
3399# Binsheng Road, Binjiang District
|
| City |
Hangzhou |
| State/province |
Zhejiang |
| ZIP/Postal code |
310005 |
| Country |
China |
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| Platforms (1) |
| GPL25749 |
Illumina HiSeq 2000 (Meriones unguiculatus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA509196 |
| SRA |
SRP173225 |
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