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| Status |
Public on Sep 14, 2020 |
| Title |
Gene expression during synaptic regeneration between cochlear hair cells and neurons |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Significant changes in the expression of synaptic and inflammatory genes were observed early after damage, during regeneration of the fibers and synapses, and after completion of in vitro regeneration between afferent neurons and cochlear hair cells.
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| Overall design |
Explants of the cochlea from early postnatal mice were exposed to kainate to induce glutamate toxicity. The organ of Corti (OC), housing the hair cells, and spiral ganglion (SG), containing the afferent neurons, were separated by dissection and mRNA analyzed by Illumina hybridization.
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| Contributor(s) |
Wu C, Brugeaud A, Yeh A, Petrillo M, Coppola G, Edge AS, Stankovic KM |
| Citation(s) |
33001981, 37240591 |
| Submission date |
Apr 30, 2019 |
| Last update date |
Aug 11, 2023 |
| Contact name |
Giovanni Coppola |
| E-mail(s) |
gcoppola@ucla.edu
|
| Phone |
310-794-4172
|
| Organization name |
UCLA
|
| Department |
Psychiatry and Neurology
|
| Lab |
Neurogenetics
|
| Street address |
1524 Gonda, 695 Charles Young Drive South
|
| City |
Los Angeles |
| State/province |
CA |
| ZIP/Postal code |
90095 |
| Country |
USA |
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| Platforms (1) |
| GPL6885 |
Illumina MouseRef-8 v2.0 expression beadchip |
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| Samples (38)
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| Relations |
| BioProject |
PRJNA540476 |
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