|
| Status |
Public on Jun 14, 2019 |
| Title |
Single Cell RNA Sequencing Identifies Subsets of Hepatic Stellate Cells and Myofibroblasts in Liver Fibrosis |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Hepatic stellate cells and activated myofibroblasts display a high heterogeneity in healthy and fibrotic liver characterized by differential expression of collagens and chemokines.
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| |
|
| Overall design |
Hepatic stellate cells and myofibroblasts were isolated from healthy and early fibrotic liver (3 weeks CCl4) and subjected to single cell RNA sequencing analysis. In vivo activated fibroblasts were then compared with in vitro generated.
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| |
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| Contributor(s) |
Krenkel O, Hundertmark J, Ritz TP, Weiskirchen R, Tacke F |
| Citation(s) |
31137713, 37620309 |
| Submission date |
Jun 13, 2019 |
| Last update date |
Sep 14, 2023 |
| Contact name |
Ali T Abdallah |
| E-mail(s) |
bioinformatics.ali.abdallah@gmail.com
|
| Organization name |
University of Cologne
|
| Department |
Medical Faculty
|
| Lab |
CECAD
|
| Street address |
Joseph Stelzmann Str. 26
|
| City |
Cologne |
| ZIP/Postal code |
50931 |
| Country |
Germany |
| |
|
| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
|
| Samples (10)
|
|
| Relations |
| BioProject |
PRJNA548680 |
| SRA |
SRP201303 |
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