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| Status |
Public on Jul 27, 2019 |
| Title |
RBMX preferentially associates with repetitive DNAs along with RPA |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
To characterize the binding sites of RBMX and RPA on chromatin, 293T cells were treated with CPT and binding profiles were obtained by ChIP-seq assay. RBMX ChIP-seq profile was highly correlated with RPA ChIP-seq profile, both showing strong peaks at centromeres. To characterize the occupancy sites bound by both RBMX and RPA, we annotated their shared peaks. The results showed that these sequences are mostly enriched on repetitive DNAs including rRNA, simple repeats and satellite DNAs.
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| |
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| Overall design |
Examination of RBMX and RPA1 binding profiles in 293T cells.
|
| |
|
| Contributor(s) |
Zheng T, Zhao Y |
| Citation(s) |
32494026 |
| Submission date |
Jul 26, 2019 |
| Last update date |
Jun 27, 2020 |
| Contact name |
Tian Zheng |
| E-mail(s) |
zhengt5@mail2.sysu.edu.cn
|
| Organization name |
Sun Yat-sen University
|
| Street address |
No. 135 West Xingang Road
|
| City |
Guangzhou |
| ZIP/Postal code |
510275 |
| Country |
China |
| |
|
| Platforms (2) |
| GPL23227 |
BGISEQ-500 (Homo sapiens) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (6)
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|
| Relations |
| BioProject |
PRJNA556911 |
| SRA |
SRP216549 |
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