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| Status |
Public on Oct 10, 2019 |
| Title |
Evaluation of the roles of Lats1 and Lats2 in the development of the Müllerian ducts |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
Development of the female tract results from the carefull coordination of numerous signaling pathways. Here, we evaluated the role of hippo pathway in the development of the female reproductive tract.
We used microarray to compare the gene expression changes observed in the Müllerian ducts of E17.5 mice embryos between control group and experimental (mutant) group bearing a conditional deletion of both (conjoint) Lats1 and Lats2 using the Amhr2cre strain.
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| Overall design |
Müllerian ducts were collected from E17.5 mice (control and experimental group) for RNA extraction and hybridization on Affymetrix microarrays. Control=Lats1f/f,Lats2f/f , Mutant=Lats1f/f,Lats2f/f,Amhr2cre/+
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| Contributor(s) |
Boerboom D, St-Jean G |
| Citation(s) |
31575647 |
| Submission date |
Aug 15, 2019 |
| Last update date |
Jan 09, 2020 |
| Contact name |
Derek Boerboom |
| E-mail(s) |
derek.boerboom@umontreal.ca
|
| Organization name |
Faculté de Médecine Vétérinaire (University of Montreal)
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| Department |
Biomédecine Vétérinaire
|
| Lab |
Derek Boerboom
|
| Street address |
3200 rue sicotte
|
| City |
St-Hyacinthe |
| State/province |
Québec |
| ZIP/Postal code |
J2S 2M2 |
| Country |
Canada |
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| Platforms (1) |
| GPL23038 |
[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay) |
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| Samples (6)
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| GSM4035492 |
Control mouse embryo at E17.5, biological replicate 1 |
| GSM4035493 |
Control mouse embryo at E17.5, biological replicate 2 |
| GSM4035494 |
Control mouse embryo at E17.5, biological replicate 3 |
| GSM4035495 |
Experimental/Mutant mouse embryo at E17.5, biological replicate 1 |
| GSM4035496 |
Experimental/Mutant mouse embryo at E17.5, biological replicate 2 |
| GSM4035497 |
Experimental/Mutant mouse embryo at E17.5, biological replicate 3 |
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| Relations |
| BioProject |
PRJNA560338 |
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