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| Status |
Public on Feb 04, 2020 |
| Title |
CBX4 role in U2OS/MTX300 |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
In our study, we found that CBX4 was critical to osteosarcoma metastasis.CBX4, also known as polycomb 2 (Pc2), belongs to the CBX protein family, including CBX2, 4, 6, 7, and 8, which has been shown to participate in the polycomb repressive complex 1 (PRC1) and characterized as a transcriptional repressor. To identify the downstream target genes of CBX4 in osteosarcoma, we conducted the RNA-seq analysis of CBX4 overexpression or knockdown in osteosarcoma cell line U2OS/MTX300.
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| Overall design |
U2OS/MTX300 cells overexpressing CBX4 are compared to Vector, and shCBX4 are compared to shControl
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| Contributor(s) |
Kang T, Wang X |
| Citation(s) |
32111827 |
| Submission date |
Nov 21, 2019 |
| Last update date |
Mar 09, 2020 |
| Contact name |
Xin Wang |
| E-mail(s) |
wangxin1@sysucc.org.cn
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| Phone |
+862087343182
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| Organization name |
Sun Yat-sen University Cancer Center
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| Street address |
Dongfengdong road 651
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| City |
Guang Zhou |
| State/province |
State... |
| ZIP/Postal code |
020-87343182 |
| Country |
China |
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| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
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| Samples (5)
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| Relations |
| BioProject |
PRJNA590871 |
| SRA |
SRP231137 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE140763_WT_vs_Vector.txt.gz |
1.5 Mb |
(ftp)(http) |
TXT |
| GSE140763_shCBX4_vs_shControl.txt.gz |
4.0 Mb |
(ftp)(http) |
TXT |
SRA Run Selector |
| Raw data are available in SRA |
| Processed data are available on Series record |
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