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| Status |
Public on May 26, 2010 |
| Title |
Altered modulation of WNT-β-catenin and PI3K/Akt pathways in IgA nephropathy |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
To uncover new molecular mechanisms involved in IgAN pathogenesis, we compared the genomic profiles of 12 IgAN patients with 8 healthy subjects,
We included addiotional disease controls 3 FSGS(Focal Segmenal glomerulosclerosis) patients and 3 membrano proliferative glomerulonephritis type I (MPGN-I) controls in our study to evaluate if the WNT-β-catenin and PI3K/Akt pathways were specfic to IgAN.
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| Overall design |
Gene expression profile comparison between 12IgAN patients and 8 Healthy Subjects. Gene Set Enrichment Analysis (GSEA) performed on the additional disease controls determined that the a priori defined set of genes and the pathways generated were specific to the IgAN
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| Contributor(s) |
Cox SN, Sallustio F, Serino G, Verrienti R, Pontrelli P, Schena FP, Zaza G, Pesce F |
| Citation(s) |
20485333 |
| Submission date |
Feb 11, 2009 |
| Last update date |
Dec 06, 2018 |
| Contact name |
Sharon Natasha Cox |
| E-mail(s) |
sharonnatasha.cox@gmail.com
|
| Organization name |
Schena Foundation
|
| Department |
Renal Lab
|
| Street address |
Strada Provinciale Valenzano-Casamassima-Km3
|
| City |
Valenzano-Bari |
| ZIP/Postal code |
70010 |
| Country |
Italy |
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| Platforms (2) |
| GPL96 |
[HG-U133A] Affymetrix Human Genome U133A Array |
| GPL571 |
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array |
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| Samples (26)
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| Relations |
| BioProject |
PRJNA112079 |
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