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| Status |
Public on Dec 31, 2021 |
| Title |
Effects of intermittent fasting on the cognitive impairment in Alzheimer's disease mice: the roles of the gut brain axis regulation mechanism |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We reported a 16-week intermittent fasting intervention alleviated cognitive impairment in Alzheimer's disease. Here we present transcriptomics data of mice hippocampus to further investigate how intermittent fasting regulates vital biological processes and pathways. After mapping clean RNA-seq reads of all mice against the Mus musculus genome, we detected 56,412 genes (including 12,527 new predicted genes) with fragments per kilobase of transcripts per million mapped reads (FPKM) value. Gene set enrichment analysis (GSEA) was used for pathway or functional analysis of RNA-seq data.
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| Overall design |
7 FAD mice,7 MAD mice,6 FAF mice, 7 MAF mice, 8 FWT mice, 7 MWT mice, 6 FWF mice, 7 MWF mice
Treatment Definitions:
FAD: female AD mice + standard feed
MAD: male AD mice + standard feed
FAF: female AD mice + intermittent fasting treatment
MAF: male AD mice + intermittent fasting treatment
FWT: female control mice + standard feed
MWT: male control mice + standard feed
FWF: female control mice + intermittent fasting treatment
MWF: male control mice + intermittent fasting treatment
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| Contributor(s) |
Jia M, Jin X |
| Citation missing |
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| Submission date |
Jan 08, 2021 |
| Last update date |
Dec 31, 2021 |
| Contact name |
Jin Xin |
| E-mail(s) |
jinxin1@genomics.cn
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| Phone |
13419631327
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| Organization name |
BGI
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| Street address |
Beishan road
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| City |
Shenzhen |
| State/province |
Guangdong |
| ZIP/Postal code |
518120 |
| Country |
China |
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| Platforms (1) |
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| Samples (55)
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| Relations |
| BioProject |
PRJNA690788 |
| SRA |
SRP300905 |
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