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| Status |
Public on Jan 12, 2021 |
| Title |
Fine particulate matter (PM2.5) promotes IgE-mediated mast cell activation through ROS/Gadd45b/JNK axis |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Background: Mast cells play an important role in allergic responses and persistently exposure to environmental fine particulate matter (PM2.5) exacerbates allergic diseases,but the details remain elucidative.
Conclusions: PM2.5 regulates ROS production through Gadd45b/MEKK4/JNK pathway, facilitating IgE-mediated mast cell activation.
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| Overall design |
RBL-2H3 cell with Normal saline and PM2.5 plus IgE+DNP-HSA
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| Contributor(s) |
Wang Y, Tang N |
| Citation missing |
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| Submission date |
Jan 11, 2021 |
| Last update date |
Jan 12, 2021 |
| Contact name |
Ying Wang |
| E-mail(s) |
xywying@csu.edu.cn
|
| Organization name |
Xiangya Hospital
|
| Street address |
Xiangya Road
|
| City |
Changsha |
| ZIP/Postal code |
410000 |
| Country |
China |
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| Platforms (1) |
| GPL18694 |
Illumina HiSeq 2500 (Rattus norvegicus) |
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| Samples (2) |
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| Relations |
| BioProject |
PRJNA691150 |
| SRA |
SRP301211 |
