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| Status |
Public on Apr 14, 2021 |
| Title |
Platelets orchestrate the resolution of pulmonary inflammation in mice through Treg repositioning and macrophage education |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
Our study investigates how interactions of platelets with regulatory T cells (Tregs) modulates the transcriptomic profile of Tregs and pro- and anti-inflammatory macrophages in the lung during resolution of pulmonary inflammation.
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| Overall design |
Pulmonary inflammation was induced by bacterial pneumonia (K. pneumonia) in mice. Single Tregs and Treg-PLT aggregates were isolated from the brochoalveolar lavage (BAL) on day 5 after induction of pneumonia. Pro- and antiinflammatory macrophages were isolated from the BAL on day 5 after induction of bacterial pneumonia from control and platelet-depleted mice.
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| |
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| Contributor(s) |
Rossaint J, Tekath T |
| Citation(s) |
34014253 |
| Submission date |
Apr 13, 2021 |
| Last update date |
Jul 14, 2021 |
| Contact name |
Jan Rossaint |
| E-mail(s) |
jan@rossaint.net
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| Organization name |
University of Münster
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| Department |
Dpt. of Anesthesiology
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| Street address |
Albert-Schweitzer-Campus 1, Bldg. A1
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| City |
Münster |
| ZIP/Postal code |
48149 |
| Country |
Germany |
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| Platforms (1) |
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| Samples (16)
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| Relations |
| BioProject |
PRJNA721629 |
| SRA |
SRP314652 |
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