|
| Status |
Public on Feb 27, 2023 |
| Title |
Ginsenoside Rg3 Reduces the Toxicity of Graphene Oxide Used for pH-Responsive Delivery of Doxorubicin to Liver and Breast Cancer Cells |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
RNA sequencing experiments revealed that the killing effect of the GO-Rg3-DOX nanoplatform proceeds primarily by downregulation of anti-apoptotic and angiogenesis related genes
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| |
|
| Overall design |
Cells were seeded onto 6-well plates at a density of 400,000 cells per well and cultured for 24 h before treatment with GO, GO-Rg3-GO-Rg3-DOX, and DOX for 6 h. Medium only was used as the negative control. Three replicates were included from each treatment. After treatment the cells were washed with PBS buffer 3 times.
|
| Web link |
https://0-www-mdpi-com.brum.beds.ac.uk/1999-4923/15/2/391
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| |
|
| Contributor(s) |
Rahimi S |
| Citation(s) |
36839713 |
| Submission date |
Oct 01, 2021 |
| Last update date |
Feb 28, 2023 |
| Contact name |
Shadi Rahimi |
| E-mail(s) |
shadi.mahshad@gmail.com, shadir@chalmers.se
|
| Organization name |
Chalmers University of Technology
|
| Department |
Department of Biology and Biological Engineering
|
| Street address |
Kemivägen 10
|
| City |
Goteborg |
| ZIP/Postal code |
41296 |
| Country |
Sweden |
| |
|
| Platforms (1) |
| GPL24676 |
Illumina NovaSeq 6000 (Homo sapiens) |
|
| Samples (12)
|
| GSM5606907 |
RNA-Seq of Huh7 cells control non-treated-rep1 [P19760_101_S32] |
| GSM5606908 |
RNA-Seq of Huh7 cells control non-treated-rep2 [P19760_102_S33] |
| GSM5606909 |
RNA-Seq of Huh7 cells control non-treated-rep3 [P19760_103_S34] |
| GSM5606910 |
RNA-Seq of Huh7 cells treated with 400ug/ml GO-rep1 [P19760_109_S35] |
| GSM5606911 |
RNA-Seq of Huh7 cells treated with 400ug/ml GO-rep2 [P19760_110_S36] |
| GSM5606912 |
RNA-Seq of Huh7 cells treated with 400ug/ml GO-rep3 [P19760_111_S37] |
| GSM5606913 |
RNA-Seq of Huh7 cells treated with 400ug/ml GO-Rg3-rep1 [P19760_117_S38] |
| GSM5606914 |
RNA-Seq of Huh7 cells treated with 400ug/ml GO-Rg3-rep2 [P19760_118_S39] |
| GSM5606915 |
RNA-Seq of Huh7 cells treated with 400ug/ml GO-Rg3-rep3 [P19760_119_S40] |
| GSM5606916 |
RNA-Seq of Huh7 cells treated with 100ug/ml GO-Rg3-DOX-rep1 [P19760_125_S41] |
| GSM5606917 |
RNA-Seq of Huh7 cells treated with 100ug/ml GO-Rg3-DOX-rep2 [P19760_126_S42] |
| GSM5606918 |
RNA-Seq of Huh7 cells treated with 100ug/ml GO-Rg3-DOX-rep3 [P19760_127_S43] |
|
| Relations |
| BioProject |
PRJNA767790 |
| SRA |
SRP339623 |
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