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GEO help: Mouse over screen elements for information. |
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| Status |
Public on May 10, 2010 |
| Title |
Gene expression data of BCR-ABL1 transformed B cell precursors from BCL6 wild-type and BCL6 knockout mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
To elucidate the mechanism of BCL6-mediated pre-B cell survival signaling, we investigated the gene expression pattern in BCR-ABL1-transformed BCL6+/+ and BCL6-/- B cell precursors. Pharmacological inhibition of BCR-ABL1 was performed with the BCR-ABL1 kinase inhibitor STI571 (Imatinib).
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| Overall design |
BCR-ABL1 transformed B cell precursors of BCL6 wildtype and BCL6 knockout mice were either treated with 10µM STI571 (Imatinib) for 16 hours or cultured in absence of STI571. Three samples for each condition were processed.
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| Contributor(s) |
Duy C, Yu JJ, Nahar R, Swaminathan S, Kweon S, Polo JM, Valls E, Klemm L, Shojaee S, Cerchietti L, Schuh W, Jäck H, Hurtz C, Ramezani-Rad P, Herzog S, Jumaa H, Koeffler PH, de Alborán IM, Melnick AM, Ye HB, Müschen M |
| Citation(s) |
20498019, 21593872, 21911423, 24821775, 23852341 |
| Submission date |
Mar 20, 2010 |
| Last update date |
Feb 11, 2019 |
| Contact name |
Markus Müschen |
| E-mail(s) |
mmuschen@chla.usc.edu
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| Phone |
+ 1 323 361 5592
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| Fax |
+1 323 361 1516
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| URL |
http://www.lymphocytes.de/
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| Organization name |
University of Southern California
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| Department |
Childrens Hospital Los Angeles
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| Lab |
Müschen Lab
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| Street address |
4650 Sunset Blvd
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| City |
Los Angeles |
| State/province |
CA |
| ZIP/Postal code |
90027 |
| Country |
USA |
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| Platforms (1) |
| GPL1261 |
[Mouse430_2] Affymetrix Mouse Genome 430 2.0 Array |
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| Samples (12)
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| GSM523989 |
Bcl6 +/+ BCR-ABL1-transformed B cell precursors - untreated 1 |
| GSM523990 |
Bcl6 +/+ BCR-ABL1-transformed B cell precursors - untreated 2 |
| GSM523991 |
Bcl6 +/+ BCR-ABL1-transformed B cell precursors - untreated 3 |
| GSM523992 |
Bcl6 +/+ BCR-ABL1-transformed B cell precursors - STI571 treated 1 |
| GSM524637 |
Bcl6 +/+ BCR-ABL1-transformed B cell precursors - STI571 treated 2 |
| GSM524638 |
Bcl6 +/+ BCR-ABL1-transformed B cell precursors - STI571 treated 3 |
| GSM524639 |
Bcl6 -/- BCR-ABL1-transformed B cell precursors - untreated 1 |
| GSM524640 |
Bcl6 -/- BCR-ABL1-transformed B cell precursors - untreated 2 |
| GSM524641 |
Bcl6 -/- BCR-ABL1-transformed B cell precursors - untreated 3 |
| GSM524642 |
Bcl6 -/- BCR-ABL1-transformed B cell precursors - STI571 treated 1 |
| GSM524643 |
Bcl6 -/- BCR-ABL1-transformed B cell precursors - STI571 treated 2 |
| GSM524644 |
Bcl6 -/- BCR-ABL1-transformed B cell precursors - STI571 treated 3 |
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| Relations |
| BioProject |
PRJNA124499 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE20987_RAW.tar |
41.4 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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