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| Status |
Public on Jan 20, 2023 |
| Title |
A Critical Role of RUNX1 in Governing Megakaryocyte-Primed Hematopoietic Stem Cell Differentiation [RNA-seq] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
RUNX1 is crucial for multiple stages of hematopoiesis and its mutation can cause familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML). We aim to study the role of RUNX1 in megakaryocyte-biased HSCs differentiation to megakaryocytes.
Here, by using Runx1F/FMx1-Cre mouse model, we sorted CD41pos HSCs and CD41neg HSCs in both RUNX1 WT and KO, and compared their gene expression profiles.
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| Overall design |
Comparative gene expression profiling analysis of RNA-seq data for CD41pos HSCs and CD41neg HSCs from both RUNX1 KO and WT mice.
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| Contributor(s) |
Wang C, Zheng Y |
| Citation(s) |
36661340 |
| Submission date |
Aug 24, 2022 |
| Last update date |
Sep 07, 2023 |
| Contact name |
Chen Wang |
| E-mail(s) |
wang2c3@mail.uc.edu
|
| Phone |
5135506715
|
| Organization name |
CCHMC
|
| Department |
Experimental Hematology/Oncology
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| Lab |
Yi Zheng
|
| Street address |
3333 Burnet Avenue
|
| City |
Cincinnati |
| State/province |
OH |
| ZIP/Postal code |
45219 |
| Country |
USA |
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| Platforms (1) |
| GPL24247 |
Illumina NovaSeq 6000 (Mus musculus) |
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| Samples (12)
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| This SubSeries is part of SuperSeries: |
| GSE212002 |
A Critical Role of RUNX1 in Governing Megakaryocyte-Primed Hematopoietic Stem Cell Differentiation |
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| Relations |
| BioProject |
PRJNA872940 |
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