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| Status |
Public on Feb 01, 2023 |
| Title |
Single-cell immune landscape of human atherosclerotic plaques |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Using single-cell proteomic and transcriptomic analyses, we uncovered distinct features of both T cells and macrophages in carotid artery plaques of patients with clinically symptomatic disease (recent stroke or transient ischemic attack) compared to asymptomatic disease (no recent stroke). Additionally, macrophages from these plaques contained alternatively activated phenotypes, including subsets associated with plaque vulnerability. In plaques from asymptomatic patients, T cells and macrophages were activated and displayed evidence of interleukin-1β signaling. The identification of specific features of innate and adaptive immune cells in plaques that are associated with cerebrovascular events may enable the design of more precisely tailored cardiovascular immunotherapies.
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| Overall design |
Carotid artery from atherosclerotic human samples, used scRNAseq to under the underlying immune molecular mechanism
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| Contributor(s) |
Giannarelli C |
| Citation(s) |
31591603, 38076343 |
| Submission date |
Feb 01, 2023 |
| Last update date |
Dec 14, 2023 |
| Contact name |
Dr. Chiara Giannarelli |
| E-mail(s) |
Chiara.Giannarelli@nyulangone.org
|
| Organization name |
NYU Langone Health
|
| Department |
Cardiology
|
| Street address |
435 E 30th St
|
| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10016 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL20301 |
Illumina HiSeq 4000 (Homo sapiens) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA930443 |
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