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Status |
Public on Aug 09, 2023 |
Title |
Affymetrix array expression data from colon polyps |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
The tubular adenoma sample cohort (accrued by Janssen Pharmaceuticals) consisted of 127 high-risk baseline adenoma samples acquired retrospectively by Avaden Biosciences. High risk patients are defined here as presenting a tubular adenoma ? 10mm, 3 or more adenomas, adenomas with villous histology or adenomas showing high-grade dysplasia based on Lieberman et al. Patients with familial adenomatous polyposis (FAP) and Lynch syndrome were excluded. All patients received at least one baseline colonoscopy for which clinical and pathological records were available. Adenoma tissue was available as archival, formalin-fixed, paraffin-embedded (FFPE) blocks.
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Overall design |
Expression dataset (N=61 samples) for the colon polyps was derived using Affymetrix Array platform (HT HG-U133 Plus PM) and was processed using affy package with Robust Multichip Average (RMA) normalization.
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Contributor(s) |
Bhandari YR, Krishna V, Powers R, Parmar S, Thursby S, Gupta E, Kulak O, Gokare P, Reumers J, Van Wesenbeeck L, Bachman KE, Baylin SB, Easwaran H |
Citation(s) |
37487069 |
Submission date |
May 26, 2023 |
Last update date |
Aug 10, 2023 |
Contact name |
Yuba R Bhandari |
E-mail(s) |
ybhanda2@jhmi.edu
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Organization name |
The Johns Hopkins University School of Medicine
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Street address |
1650 Orleans Street
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City |
Baltimore |
State/province |
MD |
ZIP/Postal code |
21287 |
Country |
USA |
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Platforms (1) |
GPL13158 |
[HT_HG-U133_Plus_PM] Affymetrix HT HG-U133+ PM Array Plate |
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Samples (61)
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This SubSeries is part of SuperSeries: |
GSE233616 |
Transcription factor expression repertoire basis for epigenetic and transcriptional subtypes of colorectal cancers |
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Relations |
BioProject |
PRJNA976732 |