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| Status |
Public on Oct 22, 2011 |
| Title |
Identification of stromally expressed molecules in the prostate by Tag profiling of cancer-associated fibroblasts, normal fibroblasts and fetal prostate |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
The stromal microenvironment plays key roles in prostate development and cancer. Cancer associated fibroblasts (CAFs) and other stromal cells stimulate tumourigenesis via several mechanisms including the expression of pro-tumourigenic factors. Mesenchyme (embryonic stroma) controls prostate organogenesis, and in some circumstances can re-differentiate prostate tumours. Epithelia are regulated by powerful paracrine signalling from the stroma in both development and disease, and identification of these stromal signals is important. We have applied next-generation Tag profiling to fetal human prostate, normal human prostate fibroblasts (NPFs) and CAFs to identify molecules expressed in prostatic stroma
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| Overall design |
Each sample was used for Tag library construction, by Solexa Inc
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| Contributor(s) |
Thomson AA |
| Citation(s) |
21804603 |
| Submission date |
Oct 29, 2010 |
| Last update date |
May 15, 2019 |
| Contact name |
Axel Thomson |
| E-mail(s) |
a.thomson@hrsu.mrc.ac.uk
|
| Phone |
+44 131 242 6221
|
| Fax |
+44 131 242 6231
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| Organization name |
MRC Human Reproductive Sciences Unit
|
| Street address |
47 Little France Crescent
|
| City |
Edinburgh |
| ZIP/Postal code |
EH16 4TJ |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL9052 |
Illumina Genome Analyzer (Homo sapiens) |
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| Samples (3) |
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| Relations |
| SRA |
SRP004042 |
| BioProject |
PRJNA134387 |
