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| Status |
Public on Dec 31, 2011 |
| Title |
Gene expression profile of butyrate mediated prevention of coloractal cancer in a mouse model |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
To further elucidate the mechanism of butyrate mediated chemoprevention of colorectal cancer,we have employed whole genome microarray expression profiling as a discovery platform to identify genes that differentially expressed in mice from Butyrate group compared those from DMH group. The mice of DMH group were received normal diet (calcium concentration,1.24%) and subcutaneous injection of 1,2-Dimethylhydrazine at a dose of 20 mg/kg once weekly for 20 weeks; the mice of Butyrate group were received high calcium diet (calcium concentration,3%) with 1.5% Butyrate and subcutaneous injection of 1,2-Dimethylhydrazine at a dose of 20 mg/kg once weekly for 20 weeks. The mice were sarcrificed at 24 week. Nine normal colonic mucosa (3 from DMH group, 3 from Butyrate group mice with tumors, and 3 from Butyrate group mice without tumors) were used for the microarray analysis.
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| Overall design |
The differentially expressed genes were identified between butyrate group and DMH group,as long as differentially expressed pathways and gene ontology terms.
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| Contributor(s) |
Chen H, Lin Y, Wang J, Fang J |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Dec 06, 2010 |
| Last update date |
Jan 12, 2017 |
| Contact name |
Jing-Yuan Fang |
| E-mail(s) |
jingyuanfang2007@126.com
|
| Organization name |
Shanghai Jiao-Tong University School of Medicine Ren-Ji Hospital
|
| Department |
Division of Gastroenterology
|
| Lab |
Shanghai Institute of Digestive Disease
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| Street address |
145 Middle Shandong Rd
|
| City |
Shanghai |
| State/province |
Shanghai |
| ZIP/Postal code |
200001 |
| Country |
China |
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| Platforms (1) |
| GPL7202 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version) |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA135735 |
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