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| Status |
Public on Jun 23, 2011 |
| Title |
B cell signature during inactive systemic lupus |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Systemic lupus erythematosous (SLE) is an autoimmune disease with an important clinical and biological heterogeneity. B lymphocytes appear central to the development of SLE which is characterized by the production of a large variety of autoantibodies and hypergammaglobulinemia. In mice, immature B cells from spontaneous lupus prone animals are able to produce autoantibodies when transferred into immunodeficient mice, strongly suggesting the existence of intrinsic B cell defects during lupus. In order to approach these defects in humans, we compared the peripheral B cell transcriptomes of quiescent lupus patients to normal B cell transcriptomes.
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| Overall design |
17 patients with quiescent lupus (patient1-17) versus 9 controls (Control1-6,Control8-10).
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| Contributor(s) |
Garaud J, Schickel J, Blaison G, Knapp A, Dembele D, Ruer-Laventie J, Korganow A, Martin T, Soulas-Sprauel P, Pasquali J |
| Citation(s) |
21886837, 23109291 |
| Submission date |
Jun 22, 2011 |
| Last update date |
Aug 23, 2019 |
| Contact name |
Jean-Nicolas SCHICKEL |
| E-mail(s) |
jnschickel@unistra.fr
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| Organization name |
CNRS UPR9021
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| Street address |
15, rue rené descartes
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| City |
STRASBOURG |
| ZIP/Postal code |
67084 |
| Country |
France |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (26)
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| Relations |
| BioProject |
PRJNA143913 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE30153_RAW.tar |
203.0 Mb |
(http)(custom) |
TAR (of CEL) |
| GSE30153_processed-data_mean_pvalue.txt.gz |
16.4 Mb |
(ftp)(http) |
TXT |
| Processed data included within Sample table |
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