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| Status |
Public on Jul 11, 2012 |
| Title |
Inflammasome-regulated cytokines are critical mediators of lung injury in humans. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
A microarray analysis involving whole blood samples isolated from critically ill patients in the medical intensive care unit at Brigham and Women's Hospital. Four groups of intubated subjects undergoing mechanical ventilation were recruited for the study: those with sepsis alone (Sepsis), those with sepsis + ARDS (se/ARDS), those with SIRS (SIRS), and those whithout sepsis, SIRS, or ARDS (untreated). Blood was obtained from patients on the day of admission (day 0) and 7 days later. RNA was isolated from the whole blood samples and microarrays were prepared to determine differential gene expression between the four groups.
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| Overall design |
Total RNA obtained from whole blood samples of critically ill patients
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| Contributor(s) |
Dolinay T, Kin YS, Howrylak J, Fredenburgh L, Massaro AF, Rogers A, Hunninghake GM, Gazourian L, Landazury R, Epannapaly S, Fyter SW |
| Citation(s) |
22461369 |
| Submission date |
Oct 09, 2011 |
| Last update date |
Dec 07, 2020 |
| Contact name |
Judie Ann Howrylak |
| Organization name |
Brigham and Women's Hospital
|
| Department |
Pulmonary and Critical Care Medicine
|
| Lab |
Augustine Choi
|
| Street address |
75 Francis Street
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02115 |
| Country |
USA |
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| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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| Samples (144)
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| Relations |
| BioProject |
PRJNA147005 |
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