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Series GSE35640 Query DataSets for GSE35640
Status Public on May 30, 2013
Title Identification of a predictive gene signature to recMAGE A3 antigen-specific cancer immunotherapy in metastatic melanoma and non-small-cell lung cancer
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Purpose: To evaluate the presence of a gene expression signature present before treatment as predictive of response to treatment with MAGE‑A3
immunotherapeutic in metastatic melanoma patients and to validate its predictivity in adjuvant therapy of early-stage lung cancer.
 
Overall design Patients were participants in two Phase II studies of the recombinant MAGE‑A3 antigen combined with immunological adjuvants. mRNA from tumor samples (biopsies) collected before MAGE-A3 immunotherapy was analyzed by microarray hybridization and by quantitative polymerase chain reaction (qRT-PCR). The melanoma microarray dataset was used to discover and crossvalidate a gene expression signature and classifier discriminative of Responders (R) versus Non-Responders (NR) patients; the gene signature and classifier were then applied to an adjuvant lung cancer study. Patients that were not included for analysis are denoted as NE (Non-evaluable).
GSK Biologicals
 
Contributor(s) Dizier B, Ulloa-Montoya F, Lehmann FF, Louahed J, Gruselle O, Brichard V
Citation(s) 23715562
Submission date Feb 08, 2012
Last update date Mar 25, 2019
Contact name Fernando Ulloa Montoya
Organization name GlaxoSmithKline Biologicals
Street address rue de l'Institut, 89
City Rixensart
ZIP/Postal code 1330
Country Belgium
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (65)
GSM872328 Melanoma tumor sample from patient 1
GSM872329 Melanoma tumor sample from patient 2
GSM872330 Melanoma tumor sample from patient 3
Relations
BioProject PRJNA152493

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE35640_RAW.tar 308.5 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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