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| Status |
Public on Jan 22, 2013 |
| Title |
mRNA profiling and clinical outcomes in human osteosarcoma (biopsies) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Osteosarcoma is a malignancy with variable outcomes that are not tightly aligned with chemotherapy response. Previous work has suggested a possible role for microRNAs (miRNAs) in determining the susceptibility of osteosarcomas to treatment but formal miRNA-based outcome models have not been reported. Formalin-fixed, paraffin-embedded (FFPE) specimens may be a unique approach for such studies in a rare malignancy. We used supervised principal components analysis and logistic regression to study survival and chemoresponse endpoints, and miRNA activity and gene set analysis algorithms to study miRNA regulatory networks using mRNA data. Our study also creates a paradigm for FFPE-based miRNA clinical biomarker research in rare tumors.
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| |
|
| Overall design |
37 unique diagnostic biopsy specimens were profiled. Samples with paired surgical resection specimens (not included in this submission) are denoted in the Sample 'characteristics' field.
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| |
|
| Contributor(s) |
Kelly A |
| Citation(s) |
23339462 |
| Submission date |
Jul 02, 2012 |
| Last update date |
Dec 22, 2017 |
| Contact name |
Katherine Hill |
| E-mail(s) |
khill5@bidmc.harvard.edu
|
| Organization name |
Beth Israel Deaconess Medical Center
|
| Department |
Medicine
|
| Lab |
Dimitrios Spentzos
|
| Street address |
330 Brookline Avenue, DA-679
|
| City |
Boston |
| State/province |
MA |
| ZIP/Postal code |
02215 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL14951 |
Illumina HumanHT-12 WG-DASL V4.0 R2 expression beadchip |
|
| Samples (37)
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| This SubSeries is part of SuperSeries: |
| GSE39058 |
microRNA- and mRNA-based studies in paraffin-archived human osteosarcoma specimens reveal profiles with reproducible and independent prognostic value |
|
| Relations |
| BioProject |
PRJNA169845 |
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