NCBI Logo
GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
          Go
Series GSE43060 Query DataSets for GSE43060
Status Public on Dec 21, 2013
Title Genomic analysis of relapsed Acute Lymphoblastic Leukaemia in children
Organism Homo sapiens
Experiment type SNP genotyping by SNP array
Genome variation profiling by SNP array
Summary Identification of de novo copy number abnormalities arising in relapsed paediatric ALL in matched presentation and relapse samples. We identified deletions of BACH2, (BTB and CNC homology 1, basic leucine zipper transcription factor 2) at relapse. To study the role of Bach2 in pre-B ALL in a genetic experiment, we transformed pre-B cells from Bach2–/– mice with BCR-ABL1. Our findings identify Bach2 as a novel tumor suppressor upstream of p53 in pre-B ALL.
 
Overall design 64 arrays (32 250K Nsp and 32 250K Sty) are included in this study. DNA was extracted from the presentation and relapse samples from 11 paediatric patients and DNA was extarcted from the remission samples from 10 patient and hybridised to the Affymetrix Human Mapping 500K Array Set.
 
Contributor(s) Rand V
Citation(s) 23852341
Submission date Dec 20, 2012
Last update date May 17, 2017
Contact name Vikki Rand
E-mail(s) vikki.rand@newcastle.ac.uk
Organization name Newcastle University
Department Northern Institute for Cancer Research
Lab Lymphoma Genomics
Street address Paul O'Gorman Building, Newcastle University
City Newcastle Upon Tyne
State/province Tyne and Wear
ZIP/Postal code NE12 4HH
Country United Kingdom
 
Platforms (2)
GPL3718 [Mapping250K_Nsp] Affymetrix Mapping 250K Nsp SNP Array
GPL3720 [Mapping250K_Sty] Affymetrix Mapping 250K Sty2 SNP Array
Samples (64)
GSM1056030 ALL_Presentation_of_Patient_L37_Nsp_Array
GSM1056031 ALL_Remission_of_Patient_L37_Nsp_Array
GSM1056032 ALL_Relapse_of_Patient_L37_Nsp_Array
Relations
BioProject PRJNA192670

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE43060.txt.gz 258 b (ftp)(http) TXT
GSE43060_Partek_CNAs_11.txt.gz 36.0 Mb (ftp)(http) TXT
GSE43060_RAW.tar 1.8 Gb (http)(custom) TAR (of CEL, CHP)
Processed data included within Sample table
Processed data provided as supplementary file
Processed data are available on Series record
| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap