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| Status |
Public on Jan 31, 2013 |
| Title |
H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence (ChIP-seq) |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
| Summary |
Cellular senescence is a tumor-suppressive program that involves chromatin reorganization and specific changes in gene expression that trigger an irreversible cell-cycle arrest. We combined quantitative mass spectrometry and ChIP deep-sequencing to identify changes in histone modification occurring during cellular senescence.
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| Overall design |
ChIP-seq was carried out using H3K4me3-specific antibodies in growing, quiescent, senescent, or senescent with shRB targeting Rb, IMR90 cells. The control mock data (ChIP-seq using anti-mouse IgG antibody) is available in GEO Sample GSM497500 (Series GSE19898).
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| |
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| Contributor(s) |
Chicas A, Lowe SW, Wang X |
| Citation(s) |
22615382 |
| Submission date |
Jan 30, 2013 |
| Last update date |
May 15, 2019 |
| Contact name |
Agustin Chicas |
| E-mail(s) |
agustin_chicas@H3biomedicine.com
|
| Organization name |
Memorial Sloan Kettering
|
| Street address |
One Bungtown Road
|
| City |
Cold Spring Harbor |
| State/province |
NY |
| ZIP/Postal code |
11724 |
| Country |
USA |
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| Platforms (1) |
| GPL9052 |
Illumina Genome Analyzer (Homo sapiens) |
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| Samples (4)
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| This SubSeries is part of SuperSeries: |
| GSE43922 |
H3K4 demethylation by Jarid1a and Jarid1b contributes to retinoblastoma-mediated gene silencing during cellular senescence |
|
| Relations |
| BioProject |
PRJNA188187 |
| SRA |
SRP018313 |
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