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| Status |
Public on Mar 29, 2013 |
| Title |
Identification of miRNAs specific for prostate cancer (PCa) |
| Platform organism |
synthetic construct |
| Sample organism |
Homo sapiens |
| Experiment type |
Non-coding RNA profiling by array
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| Summary |
The purpose of this study are: - To identify new biomarkers specific for prostate cancer (PCa) that can be used as diagnostic markers in the urine of individuals with high probability of PCa (abnormal PSA and/or digital rectal examination). - To validate the utility of these new biomarkers, as well as others already known such as PCA3, fusion gene TMPRSS2-ERG, GOLPH2 and SPINK1. - To establish a prediction model for the diagnosis of PCa based on the expression of these biomarkers. - To validate this model within the framework of an opportunist programme of early diagnosis. - Within the framework of this programme, to associate a series of social-demographic, antropometric, life-style and occupational variables for establishing a risk model predictor that could be associated with the model based on the biomarkers.
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| Overall design |
Methodology: The study is divided in three phases based on three different cohorts of patients: -Phase 1. Identification of biomarkers. This phase includes 60 patients (10 normal prostates and 50 PCa). Form these tumors a screening of miRNAs will be performed. -Phase 2. Validation of the new biomarkers and others already known by means qRT-PCR on urine samples from 300 patients (200 with histological diagnosis of PCa and 100 with an histological negative result). -Phase 3. Prospective validation in a prospective cohort iof 1065 patients included in an opportunist programme of early detection of PCa.
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| Contributor(s) |
Lopez-Guerrero JA |
| Citation(s) |
24518785 |
| Submission date |
Mar 28, 2013 |
| Last update date |
May 02, 2017 |
| Contact name |
JOSE ANTONIO LOPEZ-GUERRERO |
| E-mail(s) |
jalopez@fivo.org
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| Phone |
+34961114337
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| Fax |
+3496111001
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| Organization name |
FUNDACION INSTITUTO VALENCIANO DE ONCOLOGIA
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| Department |
LABORATORY OF MOLECULAR BIOLOGY
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| Street address |
C/PROF. BELTRAN BAGUENA, 8
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| City |
VALENCIA |
| ZIP/Postal code |
46009 |
| Country |
Spain |
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| Platforms (1) |
| GPL14613 |
[miRNA-2] Affymetrix Multispecies miRNA-2 Array |
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| Samples (60)
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| GSM1110567 |
PCa, fresh-frozen, unique replicate 11SE278 |
| GSM1110568 |
PCa, fresh-frozen, unique replicate 11SE279 |
| GSM1110569 |
PCa, fresh-frozen, unique replicate 11SE280 |
| GSM1110570 |
PCa, fresh-frozen, unique replicate 11SE281 |
| GSM1110571 |
PCa, fresh-frozen, unique replicate 11SE282 |
| GSM1110572 |
PCa, fresh-frozen, unique replicate 11SE283 |
| GSM1110573 |
PCa, fresh-frozen, unique replicate 11SE284 |
| GSM1110574 |
PCa, fresh-frozen, unique replicate 11SE286 |
| GSM1110575 |
PCa, fresh-frozen, unique replicate 11SE287 |
| GSM1110576 |
PCa, fresh-frozen, unique replicate 11SE288 |
| GSM1110577 |
PCa, fresh-frozen, unique replicate 11SE289 |
| GSM1110578 |
PCa, fresh-frozen, unique replicate 11SE291 |
| GSM1110579 |
PCa, fresh-frozen, unique replicate 11SE292 |
| GSM1110580 |
PCa, fresh-frozen, unique replicate 11SE293 |
| GSM1110581 |
PCa, fresh-frozen, unique replicate 11SE294 |
| GSM1110582 |
PCa, fresh-frozen, unique replicate 11SE295 |
| GSM1110583 |
PCa, fresh-frozen, unique replicate 11SE297 |
| GSM1110584 |
PCa, fresh-frozen, unique replicate 11SE298 |
| GSM1110585 |
PCa, fresh-frozen, unique replicate 11SE299 |
| GSM1110586 |
PCa, fresh-frozen, unique replicate 11SE300 |
| GSM1110587 |
PCa, fresh-frozen, unique replicate 11SE301 |
| GSM1110588 |
PCa, fresh-frozen, unique replicate 11SE302 |
| GSM1110589 |
PCa, fresh-frozen, unique replicate 11SE303 |
| GSM1110590 |
PCa, fresh-frozen, unique replicate 11SE304 |
| GSM1110591 |
PCa, fresh-frozen, unique replicate 11SE305 |
| GSM1110592 |
PCa, fresh-frozen, unique replicate 11SE306 |
| GSM1110593 |
PCa, fresh-frozen, unique replicate 11SE307 |
| GSM1110594 |
PCa, fresh-frozen, unique replicate 11SE308 |
| GSM1110595 |
PCa, fresh-frozen, unique replicate 11SE309 |
| GSM1110596 |
Normal prostate, fresh-frozen, unique replicate 11SE341 |
| GSM1110597 |
Normal prostate, fresh-frozen, unique replicate 11SE342 |
| GSM1110598 |
Normal prostate, fresh-frozen, unique replicate 11SE343 |
| GSM1110599 |
Normal prostate, fresh-frozen, unique replicate 11SE346 |
| GSM1110600 |
Normal prostate, fresh-frozen, unique replicate 11SE347 |
| GSM1110601 |
Normal prostate, fresh-frozen, unique replicate 11SE349 |
| GSM1110602 |
Normal prostate, fresh-frozen, unique replicate 11SE351 |
| GSM1110603 |
Normal prostate, fresh-frozen, unique replicate 11SE352 |
| GSM1110604 |
Normal prostate, fresh-frozen, unique replicate 11SE353 |
| GSM1110605 |
Normal prostate, fresh-frozen, unique replicate 11SE354 |
| GSM1110606 |
PCa, fresh-frozen, unique replicate 11SE313 |
| GSM1110607 |
PCa, fresh-frozen, unique replicate 11SE330 |
| GSM1110608 |
PCa, fresh-frozen, unique replicate 11SE332 |
| GSM1110609 |
PCa, fresh-frozen, unique replicate 11SE339 |
| GSM1110610 |
PCa, fresh-frozen, unique replicate 11SE340 |
| GSM1110611 |
PCa, fresh-frozen, unique replicate 11SE310 |
| GSM1110612 |
PCa, fresh-frozen, unique replicate 11SE314 |
| GSM1110613 |
PCa, fresh-frozen, unique replicate 11SE315 |
| GSM1110614 |
PCa, fresh-frozen, unique replicate 11SE316 |
| GSM1110615 |
PCa, fresh-frozen, unique replicate 11SE317 |
| GSM1110616 |
PCa, fresh-frozen, unique replicate 11SE324 |
| GSM1110617 |
PCa, fresh-frozen, unique replicate 11SE326 |
| GSM1110618 |
PCa, fresh-frozen, unique replicate 11SE327 |
| GSM1110619 |
PCa, fresh-frozen, unique replicate 11SE334 |
| GSM1110620 |
PCa, fresh-frozen, unique replicate 11SE323 |
| GSM1110621 |
PCa, fresh-frozen, unique replicate 11SE311 |
| GSM1110622 |
PCa, fresh-frozen, unique replicate 11SE322 |
| GSM1110623 |
PCa, fresh-frozen, unique replicate 11SE329 |
| GSM1110624 |
PCa, fresh-frozen, unique replicate 11SE338 |
| GSM1110625 |
PCa, fresh-frozen, unique replicate 11SE312 |
| GSM1110626 |
PCa, fresh-frozen, unique replicate 11SE321 |
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| Relations |
| BioProject |
PRJNA195380 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE45604_RAW.tar |
41.8 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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