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| Status |
Public on May 06, 2013 |
| Title |
Identification of differentially expressed transcripts and pathways one week and six months following implant of left ventricular devices |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
A specific set of genes involved in regulating cellular immune response, antigen presentation, and T cell activation and survival were down-regulated 7 days after LVAD placement. 6 months following LVAD placement, the expression levels of these genes were significantly increased; yet importantly, remained significantly lower than age and sex-matched samples from healthy controls.
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| |
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| Overall design |
Examination of the effect of LVAD implant on peripheral blood transcriptome. Blood was drawn before LVAD placement, 7 days post implant, and 180 days post implant. RNA sequencing was performaed on all samples.
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| |
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| Contributor(s) |
Mitchell A, Hall JL |
| Citation(s) |
24205042 |
| Submission date |
May 06, 2013 |
| Last update date |
May 15, 2019 |
| Contact name |
Rod A. Staggs |
| E-mail(s) |
stagg004@umn.edu
|
| Phone |
612-384-6451
|
| Organization name |
Minnesota Informatics
|
| Street address |
20040 Cottagewood Ave
|
| City |
Excelsior |
| State/province |
MN |
| ZIP/Postal code |
55331 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
|
| Samples (25)
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| Relations |
| BioProject |
PRJNA201433 |
| SRA |
SRP022133 |
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