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| Status |
Public on Apr 30, 2014 |
| Title |
Human blood monocyte response to IL-17A in culture |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The levels of IL-17 are elevated in the serum of psoriasis patients. However, the effects of IL-17 on circulating leukocytes bearing the IL-17 receptors are not fully understood. Of particular interest are monocytes, as the activation and recruitment of effector monocytes underlies the pathobiology of a number systemic inflammatory diseases, including psoriasis co-morbidities, such as atherosclerosis, metabolic regulation in adipose tissue and psoriatic arthritis. Human monocytes highly express both IL-17RA and IL-17RC and chemotraffick in response to IL-17. We explored the impact of IL-17 on blood monocytes. Using cDNA microarray, , we molecularly characterized how human blood monocytes respond to IL-17A in vitro.
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| Overall design |
total RNA was extratced from CD14+ monocytes (isolated from human blood) after 24hr culture with or without IL-17A (200ng/mL)
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| Contributor(s) |
Suárez-Fariñas M, Wang CQ, Nograles KE, Krueger JG |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Feb 11, 2014 |
| Last update date |
Dec 06, 2018 |
| Contact name |
Mayte Suarez-Farinas |
| E-mail(s) |
mayte.suarezfarinas@mssm.edu
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| Organization name |
Mount SinaiSchool of Medicine
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| Street address |
1425 Madison Ave, L2-70C, Box 1077,
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| City |
New York |
| State/province |
NY |
| ZIP/Postal code |
10075 |
| Country |
USA |
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| Platforms (1) |
| GPL571 |
[HG-U133A_2] Affymetrix Human Genome U133A 2.0 Array |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA237962 |
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