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Series GSE62646 Query DataSets for GSE62646
Status Public on Oct 23, 2014
Title Altered gene expression pattern in peripheral blood mononuclear cells in patients with acute myocardial infarction
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Despite a substantial progress in diagnosis and therapy, acute myocardial infarction (MI) is a major cause of mortality in the general population. A novel insight into the pathophysiology of myocardial infarction obtained by studying gene expression should help to discover novel biomarkers of MI and to suggest novel strategies of therapy. The aim of our study was to establish gene expression patterns in leukocytes from acute myocardial infarction patients.
ST-segment elevation myocardial infarction alters expression of several groups of genes. On admission, several genes and pathways that could be directly or indirectly linked with lipid/glucose metabolism, platelet function and atherosclerotic plaque stability were affected (signaling of PPAR, IL-10, IL-6). Analysis at discharge highlighted specific immune response (upregulation of immunoglobulins). Highly significant and substantial upregulation of SOCS3 and FAM20 genes expression in the first 4-6 days of myocardial infarction in all patients is the most robust observation of our work
 
Overall design Twenty-eight patients with ST-segment elevation myocardial infarction (STEMI) were included. The blood was collected on the 1st day of myocardial infarction, after 4-6 days, and after 6 months. Control group comprised 14 patients with stable coronary artery disease (CAD), without history of myocardial infarction. Gene expression analysis was performed with Affymetrix GeneChip® Human Gene 1.0 ST microarrays and GCS3000 TG system.
 
Contributor(s) Kiliszek M, Burzynska B, Michalak M, Gora M, Winkler A, Maciejak A, Leszczynska A, Gajda E, Kochanowski J, Opolski G
Citation(s) 23185530
Submission date Oct 23, 2014
Last update date Jul 26, 2018
Contact name Beata Burzynska
E-mail(s) atka@ibb.waw.pl
Organization name Institute of Biochemistry and Biophysics
Department Genetics
Street address Pawinskiego 5A
City Warsaw
ZIP/Postal code 02-106
Country Poland
 
Platforms (1)
GPL6244 [HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version]
Samples (98)
GSM1530765 Control patient with stable CAD (Control 1)
GSM1530766 Control patient with stable CAD (Control 2)
GSM1530767 Control patient with stable CAD (Control 3)
Relations
BioProject PRJNA264712

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE62646_RAW.tar 413.5 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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