|
| Status |
Public on Feb 27, 2015 |
| Title |
Investigation of the mechansim underlying the inflammatory phenotype in Group A ependymoma |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Inflammatory response has been identified as a molecular signature of high-risk Group A ependymoma (EPN). To better understand the biology of this phenotype and aid therapeutic development, transcriptomic data from Group A and B EPN patient tumor samples, and additional malignant and normal brain data, were analyzed to identify the mechanism underlying EPN group A inflammation.
Gene expression profiles of Group A and B EPN were contrasted to identify inflammatory transcriptional profiles (GSEA analysis). Candidate inflammatory mechanism genes were examined across a broader cohort of pediatric and adult brain tumor types and normal brain.
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| |
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| Overall design |
Gene expression profiles were generated from surgical tumor and normal brain samples (n=149) using Affymetrix HG-U133plus2 chips (Platform GPL570).
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| |
|
| Contributor(s) |
Donson AM |
| Citation(s) |
25968456 |
| Submission date |
Feb 27, 2015 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Andrew M Donson |
| E-mail(s) |
andrew.donson@cuanschutz.edu
|
| Phone |
303 724 4012
|
| Organization name |
CU Anschutz Medical Campus
|
| Department |
Pediatrics
|
| Lab |
RC1 North, P18-4401M
|
| Street address |
12800 E 19th Ave
|
| City |
Aurora |
| State/province |
CO |
| ZIP/Postal code |
80010 |
| Country |
USA |
| |
|
| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
|
| Samples (149)
|
|
| Relations |
| BioProject |
PRJNA276629 |
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