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| Status |
Public on Jun 01, 2020 |
| Title |
Global gene expression profiling of tissue engineered neofascia of hernia patients with good and bad healing characterisitics. |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
The prevalence of hernia after laparatomy has been estimated at 2-15%. Apart from male gender, smoking and obesity (BMI>25), increased age (>45 years) were identified as potential risk factors. To support the wound healing process, synthetic mesh is now routinely used in laparatomy.
A patient's risk for hernia formation and relapse can be estimated by his/her collagen type I / collagen type III ratio using sirius red stains.
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| Overall design |
We generated global mRNA expression profiles from 4 good and 2 bad healers obtained from native tissue and bioreactor cultures in the presence of commercially available meshs.
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| Contributor(s) |
Scholz CJ, Schulz CA, Niehaus D, Dietz UA |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Mar 12, 2015 |
| Last update date |
Jun 01, 2020 |
| Contact name |
Claus Juergen Scholz |
| Organization name |
University Hospital Würzburg
|
| Department |
Core Unit SysMed
|
| Street address |
Josef-Schneider-Str. 2
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| City |
Würzburg |
| ZIP/Postal code |
97080 |
| Country |
Germany |
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| Platforms (1) |
| GPL15207 |
[PrimeView] Affymetrix Human Gene Expression Array |
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| Samples (17)
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| GSM1632658 |
neofascia from native environment of patient CS_15 |
| GSM1632659 |
neofascia from mesh A of patient CS_15 |
| GSM1632660 |
neofascia from mesh B of patient CS_15 |
| GSM1632661 |
neofascia from native environment of patient CS_7 |
| GSM1632662 |
neofascia from mesh A of patient CS_7 |
| GSM1632663 |
neofascia from mesh B of patient CS_7 |
| GSM1632664 |
neofascia from native environment of patient CS_10 |
| GSM1632665 |
neofascia from mesh A of patient CS_10 |
| GSM1632666 |
neofascia from mesh B of patient CS_10 |
| GSM1632667 |
neofascia from native environment of patient CS_12 |
| GSM1632668 |
neofascia from mesh A of patient CS_12 |
| GSM1632669 |
neofascia from native environment of patient CS_26 |
| GSM1632670 |
neofascia from mesh A of patient CS_26 |
| GSM1632671 |
neofascia from mesh B of patient CS_26 |
| GSM1632672 |
neofascia from native environment of patient CS_43 |
| GSM1632673 |
neofascia from mesh A of patient CS_43 |
| GSM1632674 |
neofascia from mesh B of patient CS_43 |
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| Relations |
| BioProject |
PRJNA278037 |
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