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| Status |
Public on Dec 31, 2016 |
| Title |
Gene expression in peripheral blood leukocytes in young endurance athletes |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Exercise is beneficial to human’s health, and many of the effects are mediated by changes in immune function. However, the mechanisms underpinning the immune-regulatory effect of exercise remain unclear.
We used microarrays to assess the global gene expression in blood leukocytes in young endurance athletes and non-athlete controls, the differential gene expression between two groups was analzyed using bioinformatic methods and enriched biological processes and pathways were identified for up- and down-regulated genes in athletes.
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| Overall design |
Twelve young endurance athletes and 11 age-, sex- and BMI-matched healthy non-athlete controls were included. A fasting blood sample was collected from each individual at rest. Blood leukocytes were extracted, and global gene expression profile was assessed using Affymetrix human gene 1.1 ST array. Group differences in the transcriptome were analyzed using powerful bioinformatic methods (Intensity-based Hierarchical Bayes method followed by a Logistic Regression-based gene set enrichment method).
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| Contributor(s) |
Liu D, Wang R, Grant AR, Zhang J, Paul G, Wei Y, Chen P |
| Citation(s) |
28056786 |
| Submission date |
Apr 20, 2015 |
| Last update date |
Sep 12, 2019 |
| Contact name |
Dongmei Liu |
| E-mail(s) |
liudongmei@sus.edu.cn
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| Organization name |
Shanghai University of Sport
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| Department |
Sports Rehabilitation
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| Street address |
Henren Road, #188
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| City |
Shanghai |
| ZIP/Postal code |
200438 |
| Country |
China |
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| Platforms (1) |
| GPL6244 |
[HuGene-1_0-st] Affymetrix Human Gene 1.0 ST Array [transcript (gene) version] |
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| Samples (23)
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| GSM1662267 |
Leukocytes_athlete, biological rep4 |
| GSM1662268 |
Leukocytes_athlete, biological rep5 |
| GSM1662269 |
Leukocytes_athlete, biological rep6 |
| GSM1662270 |
Leukocytes_athlete, biological rep7 |
| GSM1662271 |
Leukocytes_athlete, biological rep8 |
| GSM1662272 |
Leukocytes_athlete, biological rep9 |
| GSM1662273 |
Leukocytes_athlete, biological rep10 |
| GSM1662274 |
Leukocytes_athlete, biological rep11 |
| GSM1662275 |
Leukocytes_athlete, biological rep12 |
| GSM1662276 |
Leukocytes_non_athlete, biological rep1 |
| GSM1662277 |
Leukocytes_non_athlete, biological rep2 |
| GSM1662278 |
Leukocytes_non_athlete, biological rep3 |
| GSM1662279 |
Leukocytes_non_athlete, biological rep4 |
| GSM1662280 |
Leukocytes_non_athlete, biological rep5 |
| GSM1662281 |
Leukocytes_non_athlete, biological rep6 |
| GSM1662282 |
Leukocytes_non_athlete, biological rep7 |
| GSM1662283 |
Leukocytes_non_athlete, biological rep8 |
| GSM1662284 |
Leukocytes_non_athlete, biological rep9 |
| GSM1662285 |
Leukocytes_non_athlete, biological rep10 |
| GSM1662286 |
Leukocytes_non_athlete, biological rep11 |
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| Relations |
| BioProject |
PRJNA281657 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE68072_RAW.tar |
86.0 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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