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| Status |
Public on Dec 23, 2015 |
| Title |
Comprehensive genomic analysis identify novel subtypes and targets of triple-negative breast cancer (67 not triple-negative tumors) |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Recent meta-analyses suggest triple-negative breast cancer (TNBC) is a heterogenous disease. In this study we sought to define these TNBC subtypes and identify subtype-specific markers and targets.
We identified and confirmed four distinct, stable TNBC subtypes: (1) Luminal-AR (LAR); 2) Mesenchymal (MES); 3) Basal-Like Immune-Suppressed (BLIS), and 4) Basal-Like Immune-Activated (BLIA).
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| Overall design |
RNA profiling analyses were conducted on 198 TNBC tumors (ER-negativity defined as Allred Scale value ≤2) with >50% cellularity (discovery set: n=84; validation set: n=114) and 67 not triple-negative tumors.
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| Contributor(s) |
Burstein MD, Tsimelzon A, Hilsenbeck SG, Poage G, Covington K, Fuqua SA, Chang JC, Osborne CK, Mills GB, Lau CC, Brown PH |
| Citation(s) |
25208879, 26921331 |
| Submission date |
Dec 22, 2015 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Suzanne Fuqua |
| Organization name |
Baylor College of Medicine
|
| Street address |
1 Baylor Plaza
|
| City |
Houston |
| State/province |
Texas |
| ZIP/Postal code |
77030 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (67)
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| This SubSeries is part of SuperSeries: |
| GSE76275 |
Comprehensive genomic analysis identify novel subtypes and targets of triple-negative breast cancer |
|
| Relations |
| BioProject |
PRJNA306765 |
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