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| Status |
Public on Apr 10, 2017 |
| Title |
PRDM16 represses the type I Interferon response in adipocytes [expression profiling] |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
PRDM16 is a strong activator of brown fat-specific genes, while also a repressor of white fat and muscle-specific genes. We asked what other pathways are regulated by PRDM16 in adipocytes that may be critical for brown and/or beige adipogenesis. Using microarray, we found PRDM16 also represses type I Interferon-stimulated genes (ISGs) in adipocytes.
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| Overall design |
We used microarrays to profile changes in gene expression for wildtype and Prdm16 KO adipocytes stimulated with rosiglitazone to induce browning of the adipocytes.
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| Contributor(s) |
Kissig M, Ishibashi J, Harms MJ, Lim H, Stine RR, Won K, Seale P |
| Citation(s) |
28408438 |
| Submission date |
Aug 24, 2016 |
| Last update date |
Feb 21, 2018 |
| Contact name |
Hee-Woong Lim |
| Organization name |
Cincinnati Children's Hospital Medical Center
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| Department |
Division of Biomedical Informatics
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| Street address |
3333 Burnet Ave. MLC 7024
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| City |
Cincinnati |
| State/province |
Ohio |
| ZIP/Postal code |
45229 |
| Country |
USA |
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| Platforms (1) |
| GPL16570 |
[MoGene-2_0-st] Affymetrix Mouse Gene 2.0 ST Array [transcript (gene) version] |
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| Samples (12)
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| This SubSeries is part of SuperSeries: |
| GSE86018 |
PRDM16 represses the type I Interferon response in adipocytes to promote mitochondrial and thermogenic programing |
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| Relations |
| BioProject |
PRJNA340048 |
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