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    DISP1 dispatched RND transporter family member 1 [ Homo sapiens (human) ]

    Gene ID: 84976, updated on 2-May-2024

    Summary

    Official Symbol
    DISP1provided by HGNC
    Official Full Name
    dispatched RND transporter family member 1provided by HGNC
    Primary source
    HGNC:HGNC:19711
    See related
    Ensembl:ENSG00000154309 MIM:607502; AllianceGenome:HGNC:19711
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DISPA
    Summary
    The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in lung (RPKM 5.0), testis (RPKM 4.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DISP1 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (222815039..223005995)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (222048788..222239862)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (222988381..223179337)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1836 Neighboring gene uncharacterized LOC105372984 Neighboring gene family with sequence similarity 177 member B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2583 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2584 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1837 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_5246 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1838 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1839 Neighboring gene small nucleolar RNA U13 Neighboring gene NADH:ubiquinone oxidoreductase subunit B1 pseudogene 2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:223195995-223196670 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:223197347-223198022 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:223198023-223198698 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:223198699-223199373 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:223199517-223200274 Neighboring gene 1q41-q42 HERV-mediated distal recombination region Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:223202549-223203306 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:223203307-223204064 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:223204065-223204822 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:223209992-223210672 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:223211353-223212032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:223226073-223226573 Neighboring gene uncharacterized LOC124904520 Neighboring gene uncharacterized LOC124904521

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2012-07-06)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2012-07-06)

    ClinGen Genome Curation Page

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ43740, MGC13130, MGC16796, MGC104180, DKFZp434I0428

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables peptide transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptide transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in determination of left/right symmetry IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in diaphragm development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dorsal/ventral pattern formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in patched ligand maturation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in peptide transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in smoothened signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protein dispatched homolog 1
    Names
    dispatched A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009243.2 RefSeqGene

      Range
      4951..195907
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001350630.2NP_001337559.1  protein dispatched homolog 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC093152, AL392172, BC007734, BC011542, DA062334, DA756409, HY128909
      UniProtKB/TrEMBL
      B3KPN9
      Conserved Domains (1) summary
      cl25655
      Location:192850
      Patched; Patched family
    2. NM_001369594.1NP_001356523.1  protein dispatched homolog 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC093152
      Consensus CDS
      CCDS1536.1
      UniProtKB/Swiss-Prot
      Q8N7C2, Q96F81, Q96I92, Q9H698, Q9H8H9, Q9UFA2
      Related
      ENSP00000284476.6, ENST00000284476.7
      Conserved Domains (1) summary
      cl25655
      Location:4351131
      Patched; Patched family
    3. NM_001377228.1NP_001364157.1  protein dispatched homolog 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC093152, AL392172
      Consensus CDS
      CCDS1536.1
      UniProtKB/Swiss-Prot
      Q8N7C2, Q96F81, Q96I92, Q9H698, Q9H8H9, Q9UFA2
      Related
      ENSP00000501574.1, ENST00000675039.1
      Conserved Domains (1) summary
      cl25655
      Location:4351131
      Patched; Patched family
    4. NM_001377229.1NP_001364158.1  protein dispatched homolog 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC093152, AL392172
      Consensus CDS
      CCDS1536.1
      UniProtKB/Swiss-Prot
      Q8N7C2, Q96F81, Q96I92, Q9H698, Q9H8H9, Q9UFA2
      Related
      ENSP00000502357.1, ENST00000675850.1
      Conserved Domains (1) summary
      cl25655
      Location:4351131
      Patched; Patched family
    5. NM_032890.5NP_116279.2  protein dispatched homolog 1 isoform 1

      See identical proteins and their annotated locations for NP_116279.2

      Status: REVIEWED

      Source sequence(s)
      AC093152, AL392172, BC007734, BC011542, DA062334, DA756409
      Consensus CDS
      CCDS1536.1
      UniProtKB/Swiss-Prot
      Q8N7C2, Q96F81, Q96I92, Q9H698, Q9H8H9, Q9UFA2
      Conserved Domains (1) summary
      cl25655
      Location:4351131
      Patched; Patched family

    RNA

    1. NR_165109.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    2. NR_165110.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    3. NR_165111.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    4. NR_165112.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
      Related
      ENST00000450784.5
    5. NR_165113.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
      Related
      ENST00000442171.6
    6. NR_165114.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    7. NR_165115.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    8. NR_165116.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    9. NR_165117.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
      Related
      ENST00000435378.6
    10. NR_165118.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
      Related
      ENST00000426045.5
    11. NR_165119.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    12. NR_165120.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    13. NR_165121.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
      Related
      ENST00000657452.2
    14. NR_165122.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    15. NR_165123.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    16. NR_165124.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    17. NR_165125.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
      Related
      ENST00000654502.1
    18. NR_165126.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    19. NR_165127.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    20. NR_165128.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    21. NR_165129.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    22. NR_165130.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    23. NR_165131.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    24. NR_165132.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    25. NR_165133.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    26. NR_165134.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    27. NR_165135.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    28. NR_165136.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    29. NR_165137.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    30. NR_165138.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    31. NR_165139.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    32. NR_165140.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    33. NR_165141.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    34. NR_165142.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    35. NR_165143.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
      Related
      ENST00000434872.2
    36. NR_165144.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
      Related
      ENST00000457636.5
    37. NR_165145.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    38. NR_165146.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    39. NR_165147.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    40. NR_165148.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    41. NR_165149.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    42. NR_165150.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    43. NR_165151.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    44. NR_165152.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    45. NR_165153.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    46. NR_165154.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    47. NR_165155.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
      Related
      ENST00000661663.1
    48. NR_165156.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
    49. NR_165157.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL392172
      Related
      ENST00000663328.2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      222815039..223005995
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510075.3XP_011508377.1  protein dispatched homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_011508377.1

      UniProtKB/Swiss-Prot
      Q8N7C2, Q96F81, Q96I92, Q9H698, Q9H8H9, Q9UFA2
      Conserved Domains (1) summary
      cl25655
      Location:4351131
      Patched; Patched family
    2. XM_011510073.3XP_011508375.1  protein dispatched homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_011508375.1

      UniProtKB/Swiss-Prot
      Q8N7C2, Q96F81, Q96I92, Q9H698, Q9H8H9, Q9UFA2
      Conserved Domains (1) summary
      cl25655
      Location:4351131
      Patched; Patched family
    3. XM_017002611.2XP_016858100.1  protein dispatched homolog 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8N7C2, Q96F81, Q96I92, Q9H698, Q9H8H9, Q9UFA2
      Conserved Domains (1) summary
      cl25655
      Location:4351131
      Patched; Patched family
    4. XM_011510074.3XP_011508376.1  protein dispatched homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_011508376.1

      UniProtKB/Swiss-Prot
      Q8N7C2, Q96F81, Q96I92, Q9H698, Q9H8H9, Q9UFA2
      Conserved Domains (1) summary
      cl25655
      Location:4351131
      Patched; Patched family
    5. XM_011510072.3XP_011508374.1  protein dispatched homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_011508374.1

      UniProtKB/Swiss-Prot
      Q8N7C2, Q96F81, Q96I92, Q9H698, Q9H8H9, Q9UFA2
      Conserved Domains (1) summary
      cl25655
      Location:4351131
      Patched; Patched family
    6. XM_047432763.1XP_047288719.1  protein dispatched homolog 1 isoform X1

      UniProtKB/Swiss-Prot
      Q8N7C2, Q96F81, Q96I92, Q9H698, Q9H8H9, Q9UFA2
    7. XM_006711592.3XP_006711655.1  protein dispatched homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_006711655.1

      UniProtKB/Swiss-Prot
      Q8N7C2, Q96F81, Q96I92, Q9H698, Q9H8H9, Q9UFA2
      Conserved Domains (1) summary
      cl25655
      Location:4351131
      Patched; Patched family
    8. XM_017002612.2XP_016858101.1  protein dispatched homolog 1 isoform X2

      UniProtKB/TrEMBL
      B3KPN9
      Conserved Domains (2) summary
      pfam02460
      Location:262899
      Patched; Patched family
      cl21543
      Location:313477
      MMPL; MMPL family
    9. XM_006711594.4XP_006711657.1  protein dispatched homolog 1 isoform X2

      See identical proteins and their annotated locations for XP_006711657.1

      UniProtKB/TrEMBL
      B3KPN9
      Conserved Domains (2) summary
      pfam02460
      Location:262899
      Patched; Patched family
      cl21543
      Location:313477
      MMPL; MMPL family
    10. XM_047432774.1XP_047288730.1  protein dispatched homolog 1 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      222048788..222239862
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339286.1XP_054195261.1  protein dispatched homolog 1 isoform X1

    2. XM_054339283.1XP_054195258.1  protein dispatched homolog 1 isoform X1

    3. XM_054339281.1XP_054195256.1  protein dispatched homolog 1 isoform X1

    4. XM_054339285.1XP_054195260.1  protein dispatched homolog 1 isoform X1

    5. XM_054339282.1XP_054195257.1  protein dispatched homolog 1 isoform X1

    6. XM_054339287.1XP_054195262.1  protein dispatched homolog 1 isoform X1

    7. XM_054339284.1XP_054195259.1  protein dispatched homolog 1 isoform X1

    8. XM_054339290.1XP_054195265.1  protein dispatched homolog 1 isoform X2

    9. XM_054339288.1XP_054195263.1  protein dispatched homolog 1 isoform X2

    10. XM_054339289.1XP_054195264.1  protein dispatched homolog 1 isoform X2