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    Pcyox1 prenylcysteine oxidase 1 [ Mus musculus (house mouse) ]

    Gene ID: 66881, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Pcyox1provided by MGI
    Official Full Name
    prenylcysteine oxidase 1provided by MGI
    Primary source
    MGI:MGI:1914131
    See related
    Ensembl:ENSMUSG00000029998 AllianceGenome:MGI:1914131
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PCL1; Pcly; 1200015P13Rik
    Summary
    Enables prenylcysteine oxidase activity. Acts upstream of or within prenylcysteine catabolic process. Located in lysosome. Is expressed in several structures, including genitourinary system; integumental system; limb; nervous system; and respiratory system. Orthologous to human PCYOX1 (prenylcysteine oxidase 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E18 (RPKM 36.9), placenta adult (RPKM 35.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pcyox1 in Genome Data Viewer
    Location:
    6 D1; 6 37.69 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (86362988..86374132, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (86386006..86397150, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4839 Neighboring gene small nuclear ribonucleoprotein polypeptide G Neighboring gene predicted gene, 52865 Neighboring gene STARR-positive B cell enhancer ABC_E11322 Neighboring gene STARR-seq mESC enhancer starr_16526 Neighboring gene nuclear encoded tRNA glycine 4 (anticodon CCC) Neighboring gene cytotoxic granule-associated RNA binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Prenylcysteine Oxidase 1 (PCYOX1), a New Player in Thrombosis. Banfi C, et al. Int J Mol Sci, 2022 Mar 4. PMID 35269975, Free PMC Article
    2. Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liver. Beigneux A, et al. J Biol Chem, 2002 Oct 11. PMID 12151402
    3. Prenylcysteine oxidase 1, an emerging player in atherosclerosis. Banfi C, et al. Commun Biol, 2021 Sep 21. PMID 34548610, Free PMC Article
    4. Loss of CLN7 results in depletion of soluble lysosomal proteins and impaired mTOR reactivation. Danyukova T, et al. Hum Mol Genet, 2018 May 15. PMID 29514215, Free PMC Article
    5. Proteome-wide characterization of N-glycosylation events by diagonal chromatography. Ghesquière B, et al. J Proteome Res, 2006 Sep. PMID 16944957

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Prenylcysteine oxidase 1, an emerging player in atherosclerosis.
      Title: Prenylcysteine oxidase 1, an emerging player in atherosclerosis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables FAD binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables prenylcysteine oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables prenylcysteine oxidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables prenylcysteine oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in prenylated protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in prenylated protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within prenylcysteine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in prenylcysteine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in lysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of very-low-density lipoprotein particle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    prenylcysteine oxidase 1
    Names
    prenylcysteine lyase
    NP_001342616.1
    NP_080099.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355687.1 → NP_001342616.1  prenylcysteine oxidase 1 isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      AC153374, AC155947
      UniProtKB/TrEMBL
      Q99JK4
      Conserved Domains (1) summary
      pfam07156
      Location:61 → 425
      Prenylcys_lyase; Prenylcysteine lyase

    2. NM_025823.4 → NP_080099.1  prenylcysteine oxidase 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_080099.1

      Status: VALIDATED

      Source sequence(s)
      AK004799, AK134528
      Consensus CDS
      CCDS20311.1
      UniProtKB/Swiss-Prot
      Q3UHV6, Q69ZW0, Q8BZX1, Q9CQF9
      UniProtKB/TrEMBL
      Q3TVT6, Q3UYP2
      Related
      ENSMUSP00000032065.9, ENSMUST00000032065.15
      Conserved Domains (2) summary
      pfam07156
      Location:130 → 494
      Prenylcys_lyase; Prenylcysteine lyase
      pfam13450
      Location:39 → 106
      NAD_binding_8; NAD(P)-binding Rossmann-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      86362988..86374132 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQF9.1 GenPept UniProtKB/Swiss-Prot:Q9CQF9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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