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    Ifit3b interferon-induced protein with tetratricopeptide repeats 3B [ Mus musculus (house mouse) ]

    Gene ID: 667370, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Ifit3bprovided by MGI
    Official Full Name
    interferon-induced protein with tetratricopeptide repeats 3Bprovided by MGI
    Primary source
    MGI:MGI:3698419
    See related
    Ensembl:ENSMUSG00000062488 AllianceGenome:MGI:3698419
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    I830012O16Rik
    Summary
    Predicted to enable RNA binding activity and identical protein binding activity. Predicted to be involved in defense response to virus; negative regulation of apoptotic process; and negative regulation of cell population proliferation. Predicted to be located in mitochondrion. Predicted to be active in cytosol. Orthologous to human IFIT3 (interferon induced protein with tetratricopeptide repeats 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in bladder adult (RPKM 6.3), liver E18 (RPKM 4.8) and 18 other tissues See more
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    Genomic context

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    See Ifit3b in Genome Data Viewer
    Location:
    19 C1; 19 29.76 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (34584945..34590801)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (34607530..34613403)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4275 Neighboring gene interferon-induced protein with tetratricopeptide repeats 2 Neighboring gene STARR-positive B cell enhancer ABC_E11027 Neighboring gene interferon-induced protein with tetratricopeptide repeats 3 Neighboring gene interferon induced protein with tetratricpeptide repeats 1B like 1 Neighboring gene STARR-positive B cell enhancer ABC_E11028 Neighboring gene STARR-positive B cell enhancer ABC_E5698 Neighboring gene interferon induced protein with tetratricopeptide repeats 1B like 2 Neighboring gene calponin2, pseudogene Neighboring gene interferon-induced protein with tetratricopeptide repeats 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Interferon-induced Ifit proteins: their role in viral pathogenesis. Fensterl V, et al. J Virol, 2015 Mar. PMID 25428874, Free PMC Article
    2. The broad-spectrum antiviral functions of IFIT and IFITM proteins. Diamond MS, et al. Nat Rev Immunol, 2013 Jan. PMID 23237964, Free PMC Article
    3. The sperm-associated antigen 6 interactome and its role in spermatogenesis. Liu Y, et al. Reproduction, 2019 Aug. PMID 31146259, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in antiviral innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to virus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to virus ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    interferon-induced protein with tetratricopeptide repeats 3-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001005858.3 → NP_001005858.2  interferon-induced protein with tetratricopeptide repeats 3-like

      Status: VALIDATED

      Source sequence(s)
      AC016791, AK077243, CA576017
      Consensus CDS
      CCDS50423.1
      UniProtKB/TrEMBL
      E9PV48, Q8BPC3
      Related
      ENSMUSP00000075599.6, ENSMUST00000076249.6
      Conserved Domains (3) summary
      COG5010
      Location:136 → 272
      TadD; Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures]
      sd00006
      Location:136 → 164
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:48 → 126
      TPR_12; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      34584945..34590801
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006527264.5 → XP_006527327.1  interferon-induced protein with tetratricopeptide repeats 3-like isoform X1

      UniProtKB/TrEMBL
      Q8BPC3
      Conserved Domains (2) summary
      TIGR02917
      Location:81 → 325
      PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein
      sd00006
      Location:161 → 189
      TPR; TPR repeat [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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