U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    TUSC7 tumor suppressor candidate 7 [ Homo sapiens (human) ]

    Gene ID: 285194, updated on 10-Oct-2023

    Summary

    Go to the top of the page Help
    Official Symbol
    TUSC7provided by HGNC
    Official Full Name
    tumor suppressor candidate 7provided by HGNC
    Primary source
    HGNC:HGNC:27701
    See related
    Ensembl:ENSG00000243197 MIM:616057; AllianceGenome:HGNC:27701
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LSAMPAS3; LINC00902; LSAMP-AS1; LSAMP-AS3; NCRNA00295
    Expression
    Restricted expression toward testis (RPKM 5.6) See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See TUSC7 in Genome Data Viewer
    Location:
    3q13.31
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (116709779..116717036)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (119429675..119436932)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (116428635..116435887)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 582, pseudogene Neighboring gene basic leucine zipper and W2 domains 1 pseudogene 2 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:116567636-116568270 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:116568271-116568906 Neighboring gene microRNA 4447 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14622 Neighboring gene long intergenic non-protein coding RNA 901

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. [Serum level of lncRNA TUSC7 in patients with esophageal squamous cell carcinoma and its role in promoting tumor cell migration and invasion]. Zhao K, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2020 May 30. PMID 32897196, Free PMC Article
    2. Downregulation of long noncoding RNA TUSC7 promoted cell growth, invasion and migration through sponging with miR-616-5p/GSK3β pathway in ovarian cancer. Zhu LM, et al. Eur Rev Med Pharmacol Sci, 2020 Jul. PMID 32706063
    3. LncRNA LOC285194 modulates gastric carcinoma progression through activating Wnt/β-catenin signaling pathway. Zhong B, et al. Cancer Med, 2020 Mar. PMID 31991056, Free PMC Article
    4. Long non-coding RNA LOC285194 in cancer. Luo L, et al. Clin Chim Acta, 2020 Mar. PMID 31837299
    5. Decreased expression of long non-coding LOC285194 predicts tumour progression and poor prognosis of hepatocellular carcinoma after curative hepatectomy. Qiu J, et al. Postgrad Med J, 2020 Feb. PMID 31494574

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Proposed TUSC7/miR-211/Nurr1 ceRNET Might Potentially be Disturbed by a cer-SNP rs2615499 in Breast Cancer.
      Title: A Proposed TUSC7/miR-211/Nurr1 ceRNET Might Potentially be Disturbed by a cer-SNP rs2615499 in Breast Cancer.
    2. Long non-coding RNA TUSC7 suppressed colorectal cancer progression via regulation of miR-23b/PDE7A Axis.
      Title: Long non-coding RNA TUSC7 suppressed colorectal cancer progression via regulation of miR-23b/PDE7A Axis.
    3. LOC285194 inhibits proliferation of human keratinocytes through regulating miR-616/GATA3 pathway.
      Title: LOC285194 inhibits proliferation of human keratinocytes through regulating miR-616/GATA3 pathway.
    4. lncRNA TUSC7 inhibits osteosarcoma progression through the miR181a/RASSF6 axis.
      Title: lncRNA TUSC7 inhibits osteosarcoma progression through the miR‑181a/RASSF6 axis.
    5. Downregulation of long noncoding RNA TUSC7 promoted cell growth, invasion and migration through sponging with miR-616-5p/GSK3beta pathway in ovarian cancer.
      Title: Downregulation of long noncoding RNA TUSC7 promoted cell growth, invasion and migration through sponging with miR-616-5p/GSK3β pathway in ovarian cancer.
    6. LncRNA LOC285194 modulates gastric carcinoma progression through activating Wnt/beta-catenin signaling pathway.
      Title: LncRNA LOC285194 modulates gastric carcinoma progression through activating Wnt/β-catenin signaling pathway.
    7. Decreased expression of long non-coding LOC285194 predicts tumour progression and poor prognosis of hepatocellular carcinoma after curative hepatectomy.
      Title: Decreased expression of long non-coding LOC285194 predicts tumour progression and poor prognosis of hepatocellular carcinoma after curative hepatectomy.
    8. Long non-coding RNA LOC285194 in cancer.
      Title: Long non-coding RNA LOC285194 in cancer.
    9. Long non-coding RNA TUSC7 suppresses osteosarcoma by targeting miR-211.
      Title: Long non-coding RNA TUSC7 suppresses osteosarcoma by targeting miR-211.
    10. [Serum level of lncRNA TUSC7 in patients with esophageal squamous cell carcinoma and its role in promoting tumor cell migration and invasion].
      Title: [Serum level of lncRNA TUSC7 in patients with esophageal squamous cell carcinoma and its role in promoting tumor cell migration and invasion].
    Submit: New GeneRIF Correction See all GeneRIFs (25)

    Phenotypes

    Go to the top of the page Help

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

    Go to the top of the page Help

    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

    Go to the top of the page Help

    Markers

    Other Names

    • LSAMP antisense RNA 3 (non-protein coding)
    • tumor suppressor candidate 7 (non-protein coding)

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_015391.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108687, AC108713
      Related
      ENST00000496242.6

    2. NR_186111.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108687, AC108713

    3. NR_186112.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108687, AC108713

    4. NR_186113.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC108687, AC108713

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      116709779..116717036
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      119429675..119436932
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials