Zfp442 zinc finger protein 442 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Zfp442provided by MGI
Official Full Name: zinc finger protein 442provided by MGI
Primary source: MGI:MGI:3651999
See related: Ensembl:ENSMUSG00000068130 AllianceGenome:MGI:3651999
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ZIPO-II
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 2 G3; 2 74.43 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (150244400..150293421, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (150402480..150451501, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables damaged DNA binding	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: zinc finger protein 442

Names: zinc-finger protein in podocyte II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310645.1 → NP_001297574.1 zinc finger protein 442

See identical proteins and their annotated locations for NP_001297574.1

Status: VALIDATED

Source sequence(s)

AB470967, AL935313

Consensus CDS

CCDS79853.1

UniProtKB/TrEMBL

A2AQA0

Related

ENSMUSP00000105542.2, ENSMUST00000109916.8

Conserved Domains (5) summary

smart00349
Location:4 → 57

KRAB; krueppel associated box

COG5048
Location:209 → 589

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:213 → 233

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01352
Location:4 → 43

KRAB; KRAB box

pfam13465
Location:225 → 250

zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

150244400..150293421 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011239742.4 → XP_011238044.1 zinc finger protein 442 isoform X2

Conserved Domains (3) summary

COG5048
Location:177 → 557

COG5048; FOG: Zn-finger [General function prediction only]

COG5189
Location:539 → 622

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:181 → 201

ZF_C2H2; C2H2 Zn finger [structural motif]
XM_011239741.2 → XP_011238043.1 zinc finger protein 442 isoform X1

Conserved Domains (4) summary

COG5048
Location:215 → 595

COG5048; FOG: Zn-finger [General function prediction only]

COG5189
Location:577 → 660

SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]

sd00017
Location:219 → 239

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam01352
Location:10 → 50

KRAB; KRAB box

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001177550.1: Suppressed sequence

Description

NM_001177550.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.