Ciao1 cytosolic iron-sulfur protein assembly 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ciao1provided by MGI
Official Full Name: cytosolic iron-sulfur protein assembly 1provided by MGI
Primary source: MGI:MGI:1346998
See related: Ensembl:ENSMUSG00000003662 AllianceGenome:MGI:1346998
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Wdr39
Summary: Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Predicted to act upstream of or within regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be part of CIA complex and MMXD complex. Is expressed in several structures, including central nervous system; genitourinary system; liver; neural retina; and skin. Orthologous to human CIAO1 (cytosolic iron-sulfur assembly component 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in kidney adult (RPKM 12.0), cerebellum adult (RPKM 10.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 F1; 2 61.86 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (127082858..127089736, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (127240938..127247816, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromosome segregation	IEA Inferred from Electronic Annotation more info
involved_in iron-sulfur cluster assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron-sulfur cluster assembly	ISO Inferred from Sequence Orthology more info
involved_in protein maturation by iron-sulfur cluster transfer	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of CIA complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CIA complex	ISO Inferred from Sequence Orthology more info
part_of MMXD complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: probable cytosolic iron-sulfur protein assembly protein CIAO1

Names: WD repeat domain 39; WD repeat-containing protein 39; WD40 protein Ciao1; cytosolic iron-sulfur protein assembly 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025296.4 → NP_079572.2 probable cytosolic iron-sulfur protein assembly protein CIAO1

See identical proteins and their annotated locations for NP_079572.2

Status: VALIDATED

Source sequence(s)

AK028376, BI734652, BU555826

Consensus CDS

CCDS16696.1

UniProtKB/Swiss-Prot

Q99KN2, Q9DCZ7

Related

ENSMUSP00000003759.5, ENSMUST00000003759.11

Conserved Domains (2) summary

cd00200
Location:17 → 332

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

sd00039
Location:19 → 58

7WD40; WD40 repeat [structural motif]