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    Il17rc interleukin 17 receptor C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 297520, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Il17rcprovided by RGD
    Official Full Name
    interleukin 17 receptor Cprovided by RGD
    Primary source
    RGD:1306392
    See related
    Ensembl:ENSRNOG00000027376 AllianceGenome:RGD:1306392
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable interleukin-17 receptor activity and signaling receptor binding activity. Predicted to be involved in defense response to fungus; granulocyte chemotaxis; and positive regulation of interleukin-6 production. Predicted to act upstream of or within positive regulation of cytokine production involved in inflammatory response. Predicted to be located in cell surface and plasma membrane. Human ortholog(s) of this gene implicated in chronic mucocutaneous candidiasis. Orthologous to human IL17RC (interleukin 17 receptor C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 46.0), Kidney (RPKM 45.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Il17rc in Genome Data Viewer
    Location:
    4q42
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (148174573..148187071)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (146618321..146631444)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (145426647..145439845)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene U2 spliceosomal RNA Neighboring gene jagunal homolog 1 Neighboring gene interleukin 17 receptor E Neighboring gene cysteine-rich with EGF-like domains 1 Neighboring gene proline-rich transmembrane protein 3 Neighboring gene ER membrane protein complex subunit 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of the IL-17 receptor related molecule IL-17RC as the receptor for IL-17F. Kuestner RE, et al. J Immunol, 2007 Oct 15. PMID 17911633, Free PMC Article
    2. Cutting edge: interleukin 17 signals through a heteromeric receptor complex. Toy D, et al. J Immunol, 2006 Jul 1. PMID 16785495
    3. Bone marrow derived-mesenchymal stem cells downregulate IL17A dependent IL6/STAT3 signaling pathway in CCl4-induced rat liver fibrosis. Farouk S, et al. PLoS One, 2018. PMID 30346985, Free PMC Article
    4. IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail. Ho AW, et al. J Immunol, 2010 Jul 15. PMID 20554964, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables coreceptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables interleukin-17 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-17 receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables signaling receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in defense response to fungus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in granulocyte chemotaxis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in interleukin-17A-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of cytokine production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-17 receptor C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170565.2 → NP_001164036.1  interleukin-17 receptor C precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A6IBS3, D3ZIM0
      Related
      ENSRNOP00000037747.5, ENSRNOT00000037788.7
      Conserved Domains (2) summary
      pfam08357
      Location:497 → 647
      SEFIR; SEFIR domain
      pfam15037
      Location:71 → 456
      IL17_R_N; Interleukin-17 receptor extracellular region

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      148174573..148187071
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285888.1 → XP_063141958.1  interleukin-17 receptor C isoform X13

    2. XM_017592578.3 → XP_017448067.1  interleukin-17 receptor C isoform X2

      UniProtKB/TrEMBL
      A6IBS3

    3. XM_017592577.3 → XP_017448066.1  interleukin-17 receptor C isoform X1

      UniProtKB/TrEMBL
      A6IBS3

    4. XM_017592579.3 → XP_017448068.1  interleukin-17 receptor C isoform X3

      UniProtKB/TrEMBL
      A0A8I6A339, A6IBS3
      Related
      ENSRNOP00000085036.1

    5. XM_039107409.2 → XP_038963337.1  interleukin-17 receptor C isoform X5

      Conserved Domains (2) summary
      pfam08357
      Location:369 → 519
      SEFIR; SEFIR domain
      pfam15037
      Location:112 → 328
      IL17_R_N; Interleukin-17 receptor extracellular region

    6. XM_039107411.2 → XP_038963339.1  interleukin-17 receptor C isoform X9

      Conserved Domains (2) summary
      pfam08357
      Location:354 → 504
      SEFIR; SEFIR domain
      pfam15037
      Location:43 → 313
      IL17_R_N; Interleukin-17 receptor extracellular region

    7. XM_063285883.1 → XP_063141953.1  interleukin-17 receptor C isoform X10

    8. XM_039107408.2 → XP_038963336.1  interleukin-17 receptor C isoform X4

      Conserved Domains (2) summary
      pfam08357
      Location:379 → 529
      SEFIR; SEFIR domain
      pfam15037
      Location:7 → 338
      IL17_R_N; Interleukin-17 receptor extracellular region

    9. XM_063285881.1 → XP_063141951.1  interleukin-17 receptor C isoform X6

    10. XM_039107410.2 → XP_038963338.1  interleukin-17 receptor C isoform X7

      Conserved Domains (2) summary
      pfam08357
      Location:364 → 514
      SEFIR; SEFIR domain
      pfam15037
      Location:7 → 323
      IL17_R_N; Interleukin-17 receptor extracellular region

    11. XM_063285882.1 → XP_063141952.1  interleukin-17 receptor C isoform X8

    12. XM_063285886.1 → XP_063141956.1  interleukin-17 receptor C isoform X11

    13. XM_063285884.1 → XP_063141954.1  interleukin-17 receptor C isoform X11

    14. XM_063285885.1 → XP_063141955.1  interleukin-17 receptor C isoform X11

    15. XM_039107415.2 → XP_038963343.1  interleukin-17 receptor C isoform X11

      Conserved Domains (2) summary
      pfam08357
      Location:210 → 360
      SEFIR; SEFIR domain
      pfam15037
      Location:1 → 169
      IL17_R_N; Interleukin-17 receptor extracellular region

    16. XM_063285887.1 → XP_063141957.1  interleukin-17 receptor C isoform X12

    17. XM_039107419.2 → XP_038963347.1  interleukin-17 receptor C isoform X14

      Conserved Domains (2) summary
      pfam08357
      Location:173 → 323
      SEFIR; SEFIR domain
      pfam15037
      Location:31 → 132
      IL17_R_N; Interleukin-17 receptor extracellular region

    RNA

    1. XR_005503200.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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