Igsf11 immunoglobulin superfamily, member 11 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Igsf11provided by RGD
Official Full Name: immunoglobulin superfamily, member 11provided by RGD
Primary source: RGD:1308758
See related: Ensembl:ENSRNOG00000001525 AllianceGenome:RGD:1308758
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables ionotropic glutamate receptor binding activity. Involved in maintenance of protein location and positive regulation of mini excitatory postsynaptic potential. Located in excitatory synapse and postsynaptic density. Orthologous to human IGSF11 (immunoglobulin superfamily member 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 178.8), Kidney (RPKM 164.3) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 11q21

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (75238706..75389748, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (61733139..61884059, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (64286691..64421248, complement)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D11Got45 (e-PCR)
- UniSTS:114843

RH133505 (e-PCR)
- UniSTS:216788

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ionotropic glutamate receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables ionotropic glutamate receptor binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell-cell adhesion via plasma-membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	ISS Inferred from Sequence or Structural Similarity more info
involved_in maintenance of protein location	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of long-term synaptic potentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mini excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of presynapse assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in trans-synaptic signaling	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cell-cell junction	IBA Inferred from Biological aspect of Ancestor more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in excitatory synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: immunoglobulin superfamily member 11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013120.1 → NP_001013138.1 immunoglobulin superfamily member 11 precursor

See identical proteins and their annotated locations for NP_001013138.1

Status: PROVISIONAL

Source sequence(s)

BC085929

UniProtKB/Swiss-Prot

Q5U2P2

Related

ENSRNOP00000059779.1, ENSRNOT00000066997.3

Conserved Domains (3) summary

smart00410
Location:29 → 124

IG_like; Immunoglobulin like

pfam07686
Location:27 → 141

V-set; Immunoglobulin V-set domain

cl11960
Location:156 → 223

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

75238706..75389748 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063270528.1 → XP_063126598.1 immunoglobulin superfamily member 11 isoform X1
XM_039088359.2 → XP_038944287.1 immunoglobulin superfamily member 11 isoform X1

Conserved Domains (3) summary

pfam13927
Location:99 → 160

Ig_3; Immunoglobulin domain

cd00096
Location:13 → 18

Ig; Ig strand C' [structural motif]

cl11960
Location:5 → 67

Ig; Immunoglobulin domain
XM_039088360.2 → XP_038944288.1 immunoglobulin superfamily member 11 isoform X1

Conserved Domains (3) summary

pfam13927
Location:99 → 160

Ig_3; Immunoglobulin domain

cd00096
Location:13 → 18

Ig; Ig strand C' [structural motif]

cl11960
Location:5 → 67

Ig; Immunoglobulin domain
XM_063270530.1 → XP_063126600.1 immunoglobulin superfamily member 11 isoform X3
XM_063270529.1 → XP_063126599.1 immunoglobulin superfamily member 11 isoform X2