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    Zfp458 zinc finger protein 458 [ Mus musculus (house mouse) ]

    Gene ID: 238690, updated on 8-Feb-2024

    Summary

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    Official Symbol
    Zfp458provided by MGI
    Official Full Name
    zinc finger protein 458provided by MGI
    Primary source
    MGI:MGI:3040691
    See related
    Ensembl:ENSMUSG00000055480 AllianceGenome:MGI:3040691
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf728; Gm33446; Rslcan-7; mszf59-2
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription, DNA-templated; negative regulation of transposon integration; and regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to several human genes including ZNF107 (zinc finger protein 107); ZNF43 (zinc finger protein 43); and ZNF493 (zinc finger protein 493). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Zfp458 in Genome Data Viewer
    Location:
    13 B3; 13 34.54 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (67350853..67417844, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (67225137..67278498, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2411 Neighboring gene regulator of sex limited protein 1 Neighboring gene protein FAM220A-like Neighboring gene zinc finger protein 455 Neighboring gene STARR-seq mESC enhancer starr_34895 Neighboring gene STARR-seq mESC enhancer starr_34896 Neighboring gene CapStarr-seq enhancer MGSCv37_chr13:67370040-67370149 Neighboring gene RIKEN cDNA F630042J09 gene Neighboring gene STARR-seq mESC enhancer starr_34898 Neighboring gene zinc finger protein 457

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Regulator of sex-limitation (Rsl) encodes a pair of KRAB zinc-finger genes that control sexually dimorphic liver gene expression. Krebs CJ, et al. Genes Dev, 2003 Nov 1. PMID 14563677, Free PMC Article
    2. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
    3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 728

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001152.2 → NP_001001152.1  zinc finger protein 728

      See identical proteins and their annotated locations for NP_001001152.1

      Status: VALIDATED

      Source sequence(s)
      AC159264, AC163667
      Consensus CDS
      CCDS36710.1
      UniProtKB/Swiss-Prot
      Q6P5C7
      Related
      ENSMUSP00000047222.8, ENSMUST00000045969.8
      Conserved Domains (5) summary
      smart00349
      Location:5 → 63
      KRAB; krueppel associated box
      COG5048
      Location:107 → 520
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:223 → 243
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:5 → 44
      KRAB; KRAB box
      pfam13465
      Location:348 → 372
      zf-H2C2_2; Zinc-finger double domain

    RNA

    1. NR_155551.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159264, AC163667

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      67350853..67417844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036158041.1 → XP_036013934.1  zinc finger protein 728 isoform X1

      Conserved Domains (5) summary
      smart00349
      Location:43 → 101
      KRAB; krueppel associated box
      COG5048
      Location:257 → 727
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:261 → 281
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:721 → 746
      zf-H2C2_2; Zinc-finger double domain
      NF033550
      Location:110 → 157
      transpos_ISL3; ISL3 family transposase

    2. XM_030247256.2 → XP_030103116.1  zinc finger protein 728 isoform X1

      Conserved Domains (5) summary
      smart00349
      Location:43 → 101
      KRAB; krueppel associated box
      COG5048
      Location:257 → 727
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:261 → 281
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:721 → 746
      zf-H2C2_2; Zinc-finger double domain
      NF033550
      Location:110 → 157
      transpos_ISL3; ISL3 family transposase

    3. XM_017315510.3 → XP_017170999.1  zinc finger protein 728 isoform X1

      Conserved Domains (5) summary
      smart00349
      Location:43 → 101
      KRAB; krueppel associated box
      COG5048
      Location:257 → 727
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:261 → 281
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:721 → 746
      zf-H2C2_2; Zinc-finger double domain
      NF033550
      Location:110 → 157
      transpos_ISL3; ISL3 family transposase

    4. XM_036158040.1 → XP_036013933.1  zinc finger protein 728 isoform X1

      Conserved Domains (5) summary
      smart00349
      Location:43 → 101
      KRAB; krueppel associated box
      COG5048
      Location:257 → 727
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:261 → 281
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:721 → 746
      zf-H2C2_2; Zinc-finger double domain
      NF033550
      Location:110 → 157
      transpos_ISL3; ISL3 family transposase

    5. XM_030247259.1 → XP_030103119.1  zinc finger protein 728 isoform X2

      UniProtKB/TrEMBL
      Q7M6X6
      Related
      ENSMUSP00000153284.2, ENSMUST00000225772.2
      Conserved Domains (4) summary
      smart00349
      Location:2 → 60
      KRAB; krueppel associated box
      COG5048
      Location:104 → 517
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:220 → 240
      ZF_C2H2; C2H2 Zn finger [structural motif]
      NF033550
      Location:69 → 116
      transpos_ISL3; ISL3 family transposase

    6. XM_036158043.1 → XP_036013936.1  zinc finger protein 728 isoform X2

      UniProtKB/TrEMBL
      Q7M6X6
      Conserved Domains (4) summary
      smart00349
      Location:2 → 60
      KRAB; krueppel associated box
      COG5048
      Location:104 → 517
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:220 → 240
      ZF_C2H2; C2H2 Zn finger [structural motif]
      NF033550
      Location:69 → 116
      transpos_ISL3; ISL3 family transposase

    7. XM_036158042.1 → XP_036013935.1  zinc finger protein 728 isoform X2

      UniProtKB/TrEMBL
      Q7M6X6
      Conserved Domains (4) summary
      smart00349
      Location:2 → 60
      KRAB; krueppel associated box
      COG5048
      Location:104 → 517
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:220 → 240
      ZF_C2H2; C2H2 Zn finger [structural motif]
      NF033550
      Location:69 → 116
      transpos_ISL3; ISL3 family transposase

    8. XM_030247257.2 → XP_030103117.1  zinc finger protein 728 isoform X1

      Conserved Domains (5) summary
      smart00349
      Location:43 → 101
      KRAB; krueppel associated box
      COG5048
      Location:257 → 727
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:261 → 281
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:721 → 746
      zf-H2C2_2; Zinc-finger double domain
      NF033550
      Location:110 → 157
      transpos_ISL3; ISL3 family transposase
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6P5C7.1 GenPept UniProtKB/Swiss-Prot:Q6P5C7

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