HNRNPM heterogeneous nuclear ribonucleoprotein M [Homo sapiens (human)] - Gene

Summary

Official Symbol: HNRNPMprovided by HGNC
Official Full Name: heterogeneous nuclear ribonucleoprotein Mprovided by HGNC
Primary source: HGNC:HGNC:5046
See related: Ensembl:ENSG00000099783 MIM:160994; AllianceGenome:HGNC:5046
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CEAR; HNRPM; HTGR1; NAGR1; HNRPM4; HNRNPM4; hnRNP M
Summary: This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs. This protein also constitutes a monomer of the N-acetylglucosamine-specific receptor which is postulated to trigger selective recycling of immature GlcNAc-bearing thyroglobulin molecules. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Expression: Ubiquitous expression in bone marrow (RPKM 50.0), colon (RPKM 44.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19p13.2

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (8444975..8489114)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (8432898..8476696)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (8509859..8553998)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Knockdown of HNRNPM inhibits the progression of glioma through inducing ferroptosis.
Title: Knockdown of HNRNPM inhibits the progression of glioma through inducing ferroptosis.
Targeting HNRNPM Inhibits Cancer Stemness and Enhances Antitumor Immunity in Wnt-activated Hepatocellular Carcinoma.
Title: Targeting HNRNPM Inhibits Cancer Stemness and Enhances Antitumor Immunity in Wnt-activated Hepatocellular Carcinoma.
CircURI1 interacts with hnRNPM to inhibit metastasis by modulating alternative splicing in gastric cancer.
Title: CircURI1 interacts with hnRNPM to inhibit metastasis by modulating alternative splicing in gastric cancer.
HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness.
Title: HNRNPM controls circRNA biogenesis and splicing fidelity to sustain cancer cell fitness.
RBFOX2 alters splicing outcome in distinct binding modes with multiple protein partners.
Title: RBFOX2 alters splicing outcome in distinct binding modes with multiple protein partners.
microR-505/heterogeneous nuclear ribonucleoprotein M inhibits hepatocellular carcinoma cell proliferation and induces cell apoptosis through the Wnt/beta-catenin signaling pathway.
Title: microR-505/heterogeneous nuclear ribonucleoprotein M inhibits hepatocellular carcinoma cell proliferation and induces cell apoptosis through the Wnt/β-catenin signaling pathway.
The expression of splicing factor gene HNRNPM was associated with Cognitive Decline as measured by the Mini-Mental State Examinations. Age-associated dysregulation of the splicing factor expression in ageing humans may be predictive for change in in this population.
Title: The transcript expression levels of HNRNPM, HNRNPA0 and AKAP17A splicing factors may be predictively associated with ageing phenotypes in human peripheral blood.
Our study demonstrates that hnRNPM negatively regulated prostate cancer cell migration and invasion, and its expression can be transcriptionally inhibited by YY1
Title: hnRNPM, a potential mediator of YY1 in promoting the epithelial-mesenchymal transition of prostate cancer cells.
the gain-of-function effect of a single mutation on MORC2 promotes metastasis of triple-negative breast cancer by regulating CD44 splicing mediated by hnRNPM
Title: Cancer-Associated MORC2-Mutant M276I Regulates an hnRNPM-Mediated CD44 Splicing Switch to Promote Invasion and Metastasis in Triple-Negative Breast Cancer.
The role of hnRNPM in promoting IRES-containingmRNA translationfills a critical missing piece of the hypoxia-inducedgene activation. This hnRNPM-IRES-dependent function complementsthe mRNA translation pathway mediated through eIF4E2-HIF2alphatoimplement dynamic gene regulation and offers an alternative pathfor translation recovery from stress-mediated global translationalsuppression
Title: hnRNPM induces translation switch under hypoxia to promote colon cancer development.

Submit: New GeneRIF Correction See all GeneRIFs (23)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein M (HNRNPM ), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Gag-Pol	gag-pol	Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein M (HNRNPM ), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Nef	nef	Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein M (HNRNPM ), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Pr55(Gag)	gag	Cellular biotinylated heterogeneous nuclear ribonucleoprotein M (HNRNPM) is incorporated into HIV-1 Gag virus-like particles	PubMed
	gag	Tandem affinity purification and mass spectrometry analysis identify heterogeneous nuclear ribonucleoprotein M (HNRNPM ), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into Staufen1 RNP complexes isolated from HIV-1-expressing cells	PubMed
Rev	rev	HIV-1 Rev interacting protein, heterogeneous nuclear ribonucleoprotein M (HNRNPM), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells. The interaction of Rev with HNRNPM is increased by RRE	PubMed
Tat	tat	Heterogeneous nuclear ribonucleoprotein M (HNRNPM) is identified to interact with HIV-1 Tat mutant Nullbasic in HeLa cells by LC MS/MS	PubMed
integrase	gag-pol	Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that HNRNPM gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with HNRNPM	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125827 (e-PCR)
- UniSTS:162571

RH68551 (e-PCR)
- UniSTS:42512

D11S2560 (e-PCR)
- UniSTS:37928

WI-7190 (e-PCR)
- UniSTS:55626

Hnrpm (e-PCR), detects polymorphism
- UniSTS:479129

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables RNA binding	NAS Non-traceable Author Statement more info	PubMed
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mRNA splicing, via spliceosome	IC Inferred by Curator more info	PubMed

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	IDA Inferred from Direct Assay more info	PubMed
located_in collagen-containing extracellular matrix	HDA more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in membrane	HDA more info	PubMed
located_in nuclear matrix	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in paraspeckles	IDA Inferred from Direct Assay more info	PubMed
part_of spliceosomal complex	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: heterogeneous nuclear ribonucleoprotein M

Names: CEA receptor; N-acetylglucosamine receptor 1; heterogenous nuclear ribonucleoprotein M4; hnRNA-binding protein M4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029850.1 RefSeqGene

Range

5057..49196

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001297418.2 → NP_001284347.1 heterogeneous nuclear ribonucleoprotein M isoform c

See identical proteins and their annotated locations for NP_001284347.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform c, which has a shorter N-terminus, compared to isoform a.

Source sequence(s)

AA244120, AB209733, CN350481, CN350526, HY007201

UniProtKB/TrEMBL

Q59ES8

Conserved Domains (5) summary

TIGR01628
Location:82 → 236

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12659
Location:84 → 159

RRM2_hnRNPM; RNA recognition motif 2 (RRM2) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)

cd12661
Location:519 → 595

RRM3_hnRNPM; RNA recognition motif 3 (RRM3) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)

NF033916
Location:279 → 418

antiphage_ZorA_3; anti-phage defense ZorAB system ZorA

cl17169
Location:1 → 27

RRM_SF; RNA recognition motif (RRM) superfamily
NM_005968.5 → NP_005959.2 heterogeneous nuclear ribonucleoprotein M isoform a

See identical proteins and their annotated locations for NP_005959.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a).

Source sequence(s)

BC000138, CN350526

Consensus CDS

CCDS12203.1

UniProtKB/Swiss-Prot

P52272, Q15584, Q8WZ44, Q96H56, Q9BWL9, Q9Y492

UniProtKB/TrEMBL

Q59ES8

Related

ENSP00000325376.2, ENST00000325495.9

Conserved Domains (5) summary

pfam11532
Location:41 → 70

HnRNP_M; Heterogeneous nuclear ribonucleoprotein M

cd12657
Location:72 → 147

RRM1_hnRNPM; RNA recognition motif 1 (RRM1) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)

cd12659
Location:204 → 279

RRM2_hnRNPM; RNA recognition motif 2 (RRM2) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)

cd12661
Location:654 → 730

RRM3_hnRNPM; RNA recognition motif 3 (RRM3) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)

NF033916
Location:414 → 553

antiphage_ZorA_3; anti-phage defense ZorAB system ZorA
NM_031203.4 → NP_112480.2 heterogeneous nuclear ribonucleoprotein M isoform b

See identical proteins and their annotated locations for NP_112480.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an in-frame segment in the coding region, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.

Source sequence(s)

BC008895, BC058893, CN350526, DB478004

Consensus CDS

CCDS12204.1

UniProtKB/TrEMBL

Q59ES8

Related

ENSP00000325732.2, ENST00000348943.7

Conserved Domains (5) summary

pfam11532
Location:41 → 70

HnRNP_M; Heterogeneous nuclear ribonucleoprotein M

cd12657
Location:72 → 147

RRM1_hnRNPM; RNA recognition motif 1 (RRM1) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)

cd12659
Location:165 → 240

RRM2_hnRNPM; RNA recognition motif 2 (RRM2) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)

cd12661
Location:615 → 691

RRM3_hnRNPM; RNA recognition motif 3 (RRM3) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)

NF033916
Location:375 → 514

antiphage_ZorA_3; anti-phage defense ZorAB system ZorA

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000019.10 Reference GRCh38.p14 Primary Assembly

Range

8444975..8489114

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005272479.3 → XP_005272536.1 heterogeneous nuclear ribonucleoprotein M isoform X2

See identical proteins and their annotated locations for XP_005272536.1

UniProtKB/TrEMBL

Q59ES8

Conserved Domains (4) summary

cd12386
Location:206 → 279

RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins

cd12657
Location:72 → 147

RRM1_hnRNPM; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)

cd12661
Location:636 → 712

RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)

pfam11532
Location:42 → 70

HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
XM_005272478.4 → XP_005272535.1 heterogeneous nuclear ribonucleoprotein M isoform X1

See identical proteins and their annotated locations for XP_005272535.1

UniProtKB/TrEMBL

Q59ES8

Conserved Domains (5) summary

pfam11532
Location:41 → 70

HnRNP_M; Heterogeneous nuclear ribonucleoprotein M

cd12657
Location:72 → 147

RRM1_hnRNPM; RNA recognition motif 1 (RRM1) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)

cd12659
Location:204 → 279

RRM2_hnRNPM; RNA recognition motif 2 (RRM2) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)

cd12661
Location:639 → 715

RRM3_hnRNPM; RNA recognition motif 3 (RRM3) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)

NF033916
Location:399 → 538

antiphage_ZorA_3; anti-phage defense ZorAB system ZorA
XM_017026823.2 → XP_016882312.1 heterogeneous nuclear ribonucleoprotein M isoform X3

UniProtKB/TrEMBL

Q59ES8

Conserved Domains (5) summary

TIGR01628
Location:60 → 373

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd12386
Location:206 → 279

RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins

cd12657
Location:72 → 147

RRM1_hnRNPM; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)

cd12661
Location:621 → 697

RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)

pfam11532
Location:42 → 70

HnRNP_M; Heterogeneous nuclear ribonucleoprotein M
XM_017026824.2 → XP_016882313.1 heterogeneous nuclear ribonucleoprotein M isoform X5

UniProtKB/TrEMBL

Q59ES8

Conserved Domains (4) summary

cd12386
Location:167 → 240

RRM2_hnRNPM_like; RNA recognition motif 2 in heterogeneous nuclear ribonucleoprotein M (hnRNP M) and similar proteins

cd12661
Location:597 → 673

RRM3_hnRNPM; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)

pfam11532
Location:42 → 70

HnRNP_M; Heterogeneous nuclear ribonucleoprotein M

cl17169
Location:72 → 147

RRM_SF; RNA recognition motif (RRM) superfamily
XM_005272480.3 → XP_005272537.1 heterogeneous nuclear ribonucleoprotein M isoform X4

See identical proteins and their annotated locations for XP_005272537.1

UniProtKB/TrEMBL

Q59ES8

Conserved Domains (5) summary

pfam11532
Location:41 → 70

HnRNP_M; Heterogeneous nuclear ribonucleoprotein M

cd12657
Location:72 → 147

RRM1_hnRNPM; RNA recognition motif 1 (RRM1) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)

cd12659
Location:165 → 240

RRM2_hnRNPM; RNA recognition motif 2 (RRM2) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)

cd12661
Location:600 → 676

RRM3_hnRNPM; RNA recognition motif 3 (RRM3) found in vertebrate heterogeneous nuclear ribonucleoprotein M (hnRNP M)

NF033916
Location:360 → 499

antiphage_ZorA_3; anti-phage defense ZorAB system ZorA
XM_017026825.2 → XP_016882314.1 heterogeneous nuclear ribonucleoprotein M isoform X6

UniProtKB/TrEMBL

Q59ES8
XM_047438860.1 → XP_047294816.1 heterogeneous nuclear ribonucleoprotein M isoform X7
XM_017026831.2 → XP_016882320.1 heterogeneous nuclear ribonucleoprotein M isoform X8

UniProtKB/TrEMBL

Q7KYM9
XM_017026832.2 → XP_016882321.1 heterogeneous nuclear ribonucleoprotein M isoform X9
XM_047438861.1 → XP_047294817.1 heterogeneous nuclear ribonucleoprotein M isoform X10

Alternate T2T-CHM13v2.0

Genomic

NC_060943.1 Alternate T2T-CHM13v2.0

Range

8432898..8476696

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054321059.1 → XP_054177034.1 heterogeneous nuclear ribonucleoprotein M isoform X2
XM_054321058.1 → XP_054177033.1 heterogeneous nuclear ribonucleoprotein M isoform X1
XM_054321060.1 → XP_054177035.1 heterogeneous nuclear ribonucleoprotein M isoform X3
XM_054321062.1 → XP_054177037.1 heterogeneous nuclear ribonucleoprotein M isoform X5
XM_054321061.1 → XP_054177036.1 heterogeneous nuclear ribonucleoprotein M isoform X4
XM_054321063.1 → XP_054177038.1 heterogeneous nuclear ribonucleoprotein M isoform X6
XM_054321064.1 → XP_054177039.1 heterogeneous nuclear ribonucleoprotein M isoform X7
XM_054321065.1 → XP_054177040.1 heterogeneous nuclear ribonucleoprotein M isoform X8
XM_054321066.1 → XP_054177041.1 heterogeneous nuclear ribonucleoprotein M isoform X9
XM_054321067.1 → XP_054177042.1 heterogeneous nuclear ribonucleoprotein M isoform X10