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    Bzw2 basic leucine zipper and W2 domains 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171439, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Bzw2provided by RGD
    Official Full Name
    basic leucine zipper and W2 domains 2provided by RGD
    Primary source
    RGD:621507
    See related
    Ensembl:ENSRNOG00000005096 AllianceGenome:RGD:621507
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hfb2
    Summary
    Predicted to be involved in cell differentiation and nervous system development. Predicted to be active in cytoplasm. Orthologous to human BZW2 (basic leucine zipper and W2 domains 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 1249.2), Muscle (RPKM 393.6) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Bzw2 in Genome Data Viewer
    Location:
    6q16
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (58555362..58615921, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (52828069..52888599, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (55586754..55647650, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene tetraspanin 13 Neighboring gene uncharacterized LOC134479367 Neighboring gene ankyrin repeat and MYND domain containing 2 Neighboring gene non-POU domain containing, octamer-binding, pseudogene 3 Neighboring gene leucine rich repeat containing 72 Neighboring gene MYC associated factor X, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of the novel developmentally regulated gene, Bdm2, which is highly expressed in fetal rat brain. Nishinaka N, et al. Brain Res Dev Brain Res, 2000 Mar 15. PMID 10727730
    2. E-cadherin interactome complexity and robustness resolved by quantitative proteomics. Guo Z, et al. Sci Signal, 2014 Dec 2. PMID 25468996, Free PMC Article
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in regulation of translational initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translational initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of translational initiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    eIF5-mimic protein 1
    Names
    basic leucine zipper and W2 domain-containing protein 2
    brain development-related molecule 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134402.3 → NP_599229.1  eIF5-mimic protein 1

      See identical proteins and their annotated locations for NP_599229.1

      Status: PROVISIONAL

      Source sequence(s)
      BC063149
      UniProtKB/Swiss-Prot
      Q9WTT7
      UniProtKB/TrEMBL
      A0A8I5ZSL9, A6HBA9
      Related
      ENSRNOP00000007414.2, ENSRNOT00000007414.4
      Conserved Domains (1) summary
      cd11560
      Location:218 → 408
      W2_eIF5C_like; C-terminal W2 domain of the eukaryotic translation initiation factor 5C and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      58555362..58615921 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261524.1 → XP_063117594.1  eIF5-mimic protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZSL9

    2. XM_063261525.1 → XP_063117595.1  eIF5-mimic protein 1 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WTT7.1 GenPept UniProtKB/Swiss-Prot:Q9WTT7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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